2.A.1.21.25
MFS permease of 415 aas and 12 TMSs in a 4 + 2 + 2 + 2 +2 TMS arrangement.  Tian et al. 2022 identified an MFS protein that is beneficial to L-lactic acid production by Bacillus coagulans at low pH. Adhesion forces to surfaces play an important role, next to other established driving forces, in staphylococcal channel gating. This provides an interesting extension of our understanding of transmembrane antibiotic uptake and solute efflux in infectious staphylococcal biofilms in which bacteria experience adhesive forces from a wide variety of surfaces, like those of other bacteria, tissue cells, or implanted biomaterials (Carniello et al. 2020).