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2.A.1.21.6 The tetracycline resistance efflux pump, TetA(P) (Bannam et al., 2004) (21% identity (e^-07) with 2.A.1.21.5 and 22% identity (2xe^-7) with 2.A.1.2.10). It may be the link between DHA1 and DHA3.
Accession Number:	Q46305
Protein Name:	Tetracycline efflux protein
Length:	420
Molecular Weight:	46134.00
Species:	Clostridium perfringens [1502]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Early endosome membrane¹ / Multi-pass membrane protein²
Substrate	tetracycline, tetracycline

RefSeq:	YP_001967742.1
Entrez Gene ID:	6383111
Pfam:	PF07690
Gene Ontology GO:0055085 P:transmembrane transport
References (2) [1] “The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of tetracycline-resistance determinants.” Sloan J.et.al. 8170402 [2] “Functional identification of conjugation and replication regions of the tetracycline resistance plasmid pCW3 from Clostridium perfringens.” Bannam T.L.et.al. 16788202

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MVNKLSAYKT YLLFSAITAM CFSLVATVMM VYHIEIVHLN PLQLILVGTT LELACFIFEI 
61:	PTAIVADVYS RKLSIVIGGV LTGVGFILEG SISSFVFVLV AQIVWGLGST FISGSLEAWI 
121:	AEEEKNKDLD EIYIKGAQAG QIGAFIGIVL STVIANFSVR LPIIVSGVLF IILALFLWLY 
181:	MPENNFKPSA PGDLNTFKKM VYTFKSGLKF VKSKSIIMIL LAVTLFYGLS SEGYDRLSNA 
241:	HFLQDTTLPK LGNLSSVTWF GIFGILGMIL SFIVMHFMAK NLKNEDNRKN GKLLLCINIL 
301:	YISSMLIFAL TRNFSLMLIA YLATNTFRII NKPIFSAWLN GHIDDNSRAT VLSINGQMNS 
361:	LGQILGGPII GIIATNISVS IGIVCTSLLV TPVLVLYIVA MIIDKKVDDR VGGIDYEENN

2.A.1.21.6
The tetracycline resistance efflux pump, TetA(P) (Bannam et al., 2004) (21% identity (e^-07) with 2.A.1.21.5 and 22% identity (2xe^-7) with 2.A.1.2.10). It may be the link between DHA1 and DHA3.

Cross database links:

Gene Ontology

References (2)

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Analyze:

2.A.1.21.6The tetracycline resistance efflux pump, TetA(P) (Bannam et al., 2004) (21% identity (e-07) with 2.A.1.21.5 and 22% identity (2xe-7) with 2.A.1.2.10). It may be the link between DHA1 and DHA3.

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

2.A.1.21.6
The tetracycline resistance efflux pump, TetA(P) (Bannam et al., 2004) (21% identity (e^-07) with 2.A.1.21.5 and 22% identity (2xe^-7) with 2.A.1.2.10). It may be the link between DHA1 and DHA3.