2.A.1.22.7
Synaptic vesicle glycoprotein 2B, SV2B or SLC22B2, of 683 aas and 12 TMSs in a 6 + 1 + 5 TMS arrangement. SV2B, ephrin B1 and the receptors of angiotensin II are expressed in
the podocyte, and their expressions were altered in
anti-nephrin antibody-induced nephropathy. These proteins may be involved in the development of proteinuria (Kawachi et al. 2009). SV2B and SV2C may be involved in the pathogenesis of epilepsy as well as other neurodegenerative diseases (Löscher et al. 2016) such as Alzheimer's disease and Parkinson's disease (Stout et al. 2019). Defective lysosomal acidification may provide a prognostic marker and therapeutic target for neurodegenerative diseases (Lo and Zeng 2023).
|
| Accession Number: | Q7L1I2 |
|---|
| Protein Name: | Synaptic vesicle glycoprotein 2B |
|---|
| Length: | 683 |
|---|
| Molecular Weight: | 77444.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 12 |
|---|
| Location1 / Topology2 / Orientation3: |
Cytoplasmic vesicle1 / Multi-pass membrane protein2 |
|---|
| Substrate |
|
|---|
1: MDDYKYQDNY GGYAPSDGYY RGNESNPEED AQSDVTEGHD EEDEIYEGEY QGIPHPDDVK
61: AKQAKMAPSR MDSLRGQTDL MAERLEDEEQ LAHQYETIMD ECGHGRFQWI LFFVLGLALM
121: ADGVEVFVVS FALPSAEKDM CLSSSKKGML GMIVYLGMMA GAFILGGLAD KLGRKRVLSM
181: SLAVNASFAS LSSFVQGYGA FLFCRLISGI GIGGALPIVF AYFSEFLSRE KRGEHLSWLG
241: IFWMTGGLYA SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPCTVS MVALKFMPES
301: PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSNI KTPKQMDEFI EIQSSTGTWY
361: QRWLVRFKTI FKQVWDNALY CVMGPYRMNT LILAVVWFAM AFSYYGLTVW FPDMIRYFQD
421: EEYKSKMKVF FGEHVYGATI NFTMENQIHQ HGKLVNDKFT RMYFKHVLFE DTFFDECYFE
481: DVTSTDTYFK NCTIESTIFY NTDLYEHKFI NCRFINSTFL EQKEGCHMDL EQDNDFLIYL
541: VSFLGSLSVL PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC
601: GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG ITKVVPILLA
661: AASLVGGGLI ALRLPETREQ VLM