2.A.1.3.70
Probable exporter of aromatic compounds of 559 aas and 16 putative TMSs in an apparent 4 + 4 + 4 + 4 arrangement. May function in aromatic compoound detoxification. Regulated by a MarR-like transcriptional regulator that is encoded in the same operon. Ten-fold induction occurs in response to aromatic aldehydes such as benzaldehyde (Fiorentino et al. 2007). The same MarR protein controls transcription of a gene encoding an NADH-dependent alcohol dehydrogenase (Sso2536).
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| Accession Number: | Q97YH0 |
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| Protein Name: | Permease, multidrug efflux |
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| Length: | 559 |
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| Molecular Weight: | 60491.00 |
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| Species: | Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [273057] |
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| Number of TMSs: | 16 |
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| Substrate |
aromatic compound, arenecarbaldehyde |
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1: MQYKWVALSN TTIGVLMASI NGTITLISLP AIFRGININP FTSFQYLLWI LMGYNVVTAT
61: LLVSFGRLSD IFGRVRLYNL GFLIFTIGSI LLFLTPNTGS LGALELILFR IIQGIGGAFL
121: FANSAAIITD AFPFNERGKA LGINQIAALA GSLVGLILGG ILSVIDWRYI FLVSVPVGIL
181: GTIWSYTKLK EISVPSRSEG IDWAGNTTFG LGLILILIAI TYGLLPYGSS QLGWGNPFVI
241: GSMVAGIGLI GAFIYIENKV KYPMFRLELF KIRMFTAGNL ASFLRSIAYG GLMIMLIIFL
301: QGIWLPLHGY SYEETPFWAG IYTIPLMIGF VTMGPISGWL SDRYGARLLA TLGMVIVGIG
361: FLLLTLLPYN FNYPEFALII FIMGLGNGMF ASPNTASIMN SVPPKYRGVA SGMRATIQNT
421: GQTLSMALFF TIVIISLAST LPTALANAVT QAGAPQLAPL MQKIPVTGAL FAAFLGYDPV
481: KTILSSLPPQ ITVPPQAVAV MEQHDWFPTV IAPSFMIALR EAFYISSVLT FIAAIASALR
541: GRRVIAEQQD GGEINAKNR