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|---|---|
| Accession Number: | Q9GQQ0 |
| Protein Name: | Protein spinster |
| Length: | 605 |
| Molecular Weight: | 65820.00 |
| Species: | [7227] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Late endosome membrane1 / Multi-pass membrane protein2 |
| Substrate | sphingosine 1-phosphate |
Cross database links:
| RefSeq: | NP_524823.1 NP_725530.1 NP_725531.1 NP_725532.1 NP_725533.1 |
|---|---|
| Entrez Gene ID: | 45380 |
| Pfam: | PF07690 |
| KEGG: | dme:Dmel_CG8428 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0031902
C:late endosome membrane
GO:0005765
C:lysosomal membrane
GO:0007619
P:courtship behavior
GO:0008333
P:endosome to lysosome transport
GO:0035193
P:larval central nervous system remodeling
GO:0006869
P:lipid transport
GO:0040011
P:locomotion
GO:0048477
P:oogenesis
GO:0007422
P:peripheral nervous system development
GO:0012501
P:programmed cell death
GO:0045924
P:regulation of female receptivity
GO:0045477
P:regulation of nurse cell apoptosis
GO:0008582
P:regulation of synaptic growth at neuromuscu...
GO:0051124
P:synaptic growth at neuromuscular junction
GO:0048488
P:synaptic vesicle endocytosis
GO:0055085
P:transmembrane transport
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References (6)[1] “Mutations in the novel membrane protein spinster interfere with programmed cell death and cause neural degeneration in Drosophila melanogaster.” Nakano Y.et.al. 11340170 [2] “The genome sequence of Drosophila melanogaster.” Adams M.D.et.al. 10731132 [3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.” Misra S.et.al. 12537572 [4] “A Drosophila full-length cDNA resource.” Stapleton M.et.al. 12537569 [5] “Unrestricted synaptic growth in spinster-a late endosomal protein implicated in TGF-beta-mediated synaptic growth regulation.” Sweeney S.T.et.al. 12408844 [6] “Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer.” Dermaut B.et.al. 15998804
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSLKHQKQSY QPLPTAAAMD NPAMIQSSGS SGSSSSEEGG SREDVANLSP LGLPTTYSSQ 61: QLMPSDTDSM EEERHRLRPH HHHHHPLGEH HHIPGIPPSA VVPSRLSSVG RSQWFTVTVL 121: CFVNLINYMD RFTIAGVLTD VRNDFDIGND SAGLLQTVFV ISYMVCAPIF GYLGDRYSRP 181: WIMAVGVGLW STTTLLGSFM KQFGWFIAFR ALVGIGEASY STIAPTIISD LFVHDMRSKM 241: LALFYFAIPV GSGLGYIVGS KTAHLANDWR WALRVTPILG IVAVFLILLI KDPVRGHSEG 301: SHNLEATTYK QDIKALVRNR SFMLSTAGFT CVAFVAGALA WWGPSFIYLG MKMQPGNENI 361: VQDDVAFNFG VITMLAGLLG VPLGSFLSQY LVKRYPTADP VICAFGLLVS APLLTGACLL 421: VNSNSVGTYA LIFFGQLALN LNWAIVADIL LYVVVPTRRS TAEAFQILIS HALGDAGSPY 481: LVGAISEAIM KHLHKNPSDS GLTTELRSMS QVAGSAISNA TQVIAEATTS LMETARSSAS 541: QEYSDVEQFE GLQYALFSTS FVEVLGGIFF IFTACFIIKD KYNATRGLQD ATAQQQQRDE 601: RGQIA