2.A.1.53.7
MFS uptake permease, probably specific for pyrimidines, PhtD of 427 aas and 12
TMSs. Together with PhtC (TC# 2.A.1.53.6), it contributes to
protection of L. pneumophila from dTMP starvatioin, protects the cell from 5-fluorodeoxyuridine (FUdR) toxicity and is required for growth of L. pneumophila in macrophage (Fonseca et al. 2014).
|
| Accession Number: | I7HKH2 |
|---|
| Protein Name: | Major facilitator family transporter |
|---|
| Length: | 427 |
|---|
| Molecular Weight: | 47051.00 |
|---|
| Species: | Legionella pneumophila subsp. pneumophila [91891] |
|---|
| Number of TMSs: | 12 |
|---|
| Substrate |
pyrimidine, floxuridine |
|---|
1: MQVVDEFKAF DVKASLMPWL VCFAATMFFF YEFIQGNMFA SIAANIMQDF QIQADKMAYL
61: SSIYYLANVI FLFIAGMVLD RFSIKNTILI AMFLCVISTF ILSYSDSFYV ALFCRFVTGI
121: GSAFCFLGPV RLASHWFPPQ RMALVTGAIV TVAMTGGMLA QYPLTKLVLY VGWRQAVQDV
181: GILGLAMLVL MFFWIKERPQ VAIKKEGKPI NVLVAARKAY LNAQNLRAAL YTSLMNMAIA
241: VFGAMMGTLY LEQRLGISPD QAAMINGMLF FGAIIGSPLM GWISDKVGLR VLPMKGGVLA
301: SLFILLGVLY LPVSVTMMAV LFFLLGLFTS AQVISYALVA ESSPPMMTAT AVSVVSILTQ
361: GGYLIYQNLF SALLTNYGDV RLINGVPVYL LEAYQHAAII LPIGLLIALL LLFGLKETRC
421: QQVEHTV