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2.A.1.58.3
UNC93-like protein MFSD11 (Major facilitator superfamily domain-containing protein 11; Protein ET) of 449 aas and 12 TMSs It seems to be involved in intracellular transport in mammals and has been suggested to be a sugar:H+ symporter (Zhang et al. 2018). It is expressed in testis, small intestine, spleen, prostate, and ovary, and mutations can give rise to ovarian canceer (Liu et al. 2002). Its transcript is highly enriched in Aedes aegypti during arbovirus infection (Campbell et al. 2011). UNC93A and SV2 (TC# 2.A.1.22.1) may play a role in virus assembly or budding (Campbell et al. 2011). TMEM132C, UNC93A and TTLL2 (the latter two genes being adjacent) are associated with pulmonary function (Son et al. 2015). It may be involved in psoriasis, a common chronic autoimmune inflammatory skin disease (Li et al. 2020).

Accession Number:Q8BJ51
Protein Name:UNC93-like protein MFSD11
Length:449
Molecular Weight:49133.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Genevestigator: Q8BJ51 Q8BJ51
HEGENOM: HOG000008022 HOG000008022
Entrez Gene ID: 69900    69900   
Pfam: PF05978    PF05978   
KEGG: mmu:69900    mmu:69900   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0016021 C:integral to membrane

References (10)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene.”  Sureau A.et.al.   9358160
[5] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319
[6] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[7] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene.”  Sureau A.et.al.   9358160
[10] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319

External Searches:

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Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSPESKKLFN IVILGVAFMF MFTAFQTCGN VAQTVIRSLN STDFHGSGYT SLAIIYGVFS 
61:	ASNLITPSVV AIVGPQISMF VSGLFYSMYI AVFIQPFPWS FYTASVFIGI AAAVLWTAQG 
121:	NCLTINSDEH TIGRNSGIFW ALLQSSLFFG NLYIYFAWQG KTQISEHDRR TVFIALTVIS 
181:	LVGTVLFFLI RKPDPENVLG EEESCDDQDM EATESAQNNV TKAVDAFKKS LRLCVTREML 
241:	LLSVTTAYTG LELTFFSGVY GTCIGAVNKF GTEEKSLIGL SGIFIGIGEI LGGSLFGLLS 
301:	KNSRFGRNPV VLLGTLVHFV AFYLIFLNMP GDAPIAPVEG TNSIAYIRPS KEVAILCSFL 
361:	LGLGDSCFNT QLLSILGFLY SEDSAPAFAV FKFVQSICAA VAFFYSNYLL LHWQLLVMVI 
421:	FGFFGTISFF AVEWDAAAIV ARGSDYRSI