2.A.1.6.11
Acetate/haloacid transporter, Dehp2, with a possible atypical topology (Tse et al. 2009). Transports acetate, chloroacetate, bromoacetate, 2-chloropropionate, and possibly, with low affinity, glycolate, lactate and pyruvate (based on weak inhibition results). Inducible by chloroacetate (Su and Tsang 2012). This protein is 79% identical to its paralogue, Deh4p (TC# 2.A.1.6.8) which differs in that it shows lower apparent affinity for 2-chloropropionate.
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Accession Number: | F8SVK1 |
Protein Name: | Putative haloacid permease |
Length: | 552 |
Molecular Weight: | 59233.00 |
Species: | Burkholderia sp. MBA4 [483010] |
Number of TMSs: | 12 |
Substrate |
acetate, (S)-2-halocarboxylic acid, lactate, glycolate, pyruvate |
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1: MATVSGQISH APMTKEEKRV IFASSLGTVF EWYDFYLAGS LAAFISKSFF SGVNPTAAFI
61: FTLLGFAAGF AVRPFGALVF GRLGDMVGRK YTFLITIVIM GLSTCVVGFL PGYAAIGMAS
121: PVIFIAMRLL QGLALGGEYG GAATYVAEHA PANRRGFYTA WIQTTATLGL FLSLLVILGV
181: RTAMGEDAFG AWGWRIPFVA SLVLLGISVW IRMQLHESPA FERIKAEGKT SKAPLSEAFG
241: QWKNLKIVIL ALIGVTAGQA VVWYTGQFYA LFFLTQTLKV DGASANILIA IALLIGTPFF
301: LFFGSLSDRI GRKPIILAGC LIAALTYFPL FKALTHYANP ALEAATQKSP IVVIANPDEC
361: SFQFNPVGTS KFTSSCDIAK SALSKAGLNY DNVAAPAGTL AQIKVGDTTI DTYDGKAADA
421: KDAGKAFDKN LGTALKAASY PPKADPSQLN WPMTVVILTI LVIYVTMVYG PIAAMLVEMF
481: PTRIRYTSMS LPYHIGNGWF GGFLPATAFA IVAAKGNIYS GLWYPIIIAL ATFVIGLLFV
541: RETKDSNIYA QD