2.A.1.65.13
MFSD6 of 791 aas and 12 TMSs in a 3 + 3 + 6 TMS arrangement. Mutations in the mfsd-6 gene influence the regulation of neural circuit activity (McCulloch et al. 2017). MfsD6 may transport sugars. Expression levels of Mfsd6 and Mfsd10 were decreased with elevated or depleted energy consumption, while that of Mfsd8 remained unaffected (Bagchi et al. 2020).
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| Accession Number: | Q6ZSS7 |
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| Protein Name: | Major facilitator superfamily domain-containing protein 6 |
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| Length: | 791 |
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| Molecular Weight: | 88088.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MADDKVAILT DDEEEQKRKY VLADPFNGIS REPEPPSNET PSSTETSAIP EEEIDWIEKH
61: CVKINNDLLI SKVFYFFFYS AYGSLYPLLP VYYKQLGMSP SQSGLLVGIR YFIEFCSAPF
121: WGVVADRFKK GKIVLLFSLL CWVLFNLGIG FVKPATLRCV PKIRPTTHPT NASHQLTILP
181: TNSSFTSFLT ISPKMREKRN LLETRLNVSD TVTLPTAPNM NSEPTLQPQT GEITNRMMDL
241: TLNSSTATPV SPGSVTKETT TVIVTTTKSL PSDQVMLVYD QQEVEAIFLV ILVVVIIGEF
301: FSASSVTIVD TVTLQYLGKH RDRYGLQRMW GSLGWGLAML SVGIGIDYTH IEVLIDGKGC
361: KPPEYRNYQI VFIVFGVLMT MALIVATQFR FRYNHFKNDD SKGKEVEIPQ VERNNSTESS
421: EETPTTTSHS QAFNFWDLIK LLCSVQYGSV LFVAWFMGFG YGFVFTFLYW HLEDLNGTTT
481: LFGVCSVLSH VSELTAYFFS HKLIELIGHI RVLYIGLACN TARYIYISYL ENAWTVLPME
541: VLQGVTHAAI WAACISYLSA AVPPELRTSA QGILQGLHLG LGRGCGAMIG GVLVNYFGAA
601: ATFRGIGMAC LVILLLFALI QWLAVPDEEE DKTMLAERIP VPSSPVPIAT IDLVQQQTED
661: VMPRIEPRLP PKKTKHQEEQ EDVNKPAWGV SSSPWVTFVY ALYQIKEMMQ LTRDNRASEI
721: QPLQGTNENR ENSPAGRAQP VPCETHSDPS RNQPSPDAAA SQTQTSPAHP SVDPCTEESE
781: EQQAQLAAGG H