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2.A.1.7.4
Rat kidney Na+-dependent glucose (methyl α-glucoside) transporter, NaGLT1 or SGLT1 (glucose:Na+:Na+=1:1) (Horiba et al., 2003). Position 170 of Rabbit Na+/glucose cotransporter (rSGLT1) lies in the Na+ pathway, and modulation of polarity/charge at this site regulates charge transfer and carrier turnover (Huntley et al. 2004). The fine-tuning of glucose uptake mechanisms is rendered by various glucose transporters with distinct transport characteristics. In the pancreatic islet, facilitative diffusion glucose transporters (GLUTs), and sodium-glucose cotransporters (SGLTs) contribute to glucose uptake and represent important components in the glucose-stimulated hormone release from endocrine cells, therefore playing a crucial role in blood glucose homeostasis (Berger and Zdzieblo 2020). SGLT1 and SGLT2 are therapeutic targets for various diseases (Sano et al. 2020), and function in glucose absorption in the small intestine (Vallon 2020).

Accession Number:Q80T22
Protein Name:NaGLT1
Length:484
Molecular Weight:51775.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Multi-pass membrane protein2
Substrate glucose

Cross database links:

Genevestigator: Q80T22
eggNOG: roNOG15543
RefSeq: NP_788269.1   
Entrez Gene ID: 337920   
Pfam: PF07690   
KEGG: rno:337920   

Gene Ontology

GO:0016324 C:apical plasma membrane
GO:0016021 C:integral to membrane
GO:0005355 F:glucose transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0008643 P:carbohydrate transport
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (2)

[1] “Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney.”  Horiba N.et.al.   12590146
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MEFRGSGATA VEQHLLQSET PGKNGLQATS SDQVGRTLRW FTTVVLNAAF LGMGVSAAVL 
61:	GPTFPDLARN VNRNISSLSE IFVGRALGYL GGSVVGGVLF DCMNHFLLLG LSHLLTAAGL 
121:	YLTPFCKTAA LLTAMMSITG VSFGVLDTGG NVLILDLWGD KGAPHIQALH FSFALGAFLA 
181:	PLLAKLAWGT TASAQNHTEP QLDRSALNRS FEAASDSVLA VPDDMNLLWA YASIGTYVLV 
241:	LSVFLFAPFF KKRSKQKKSA ASAQGARRAK YHRALLCLLF LFFFFYVGAE VTYGSYVFSF 
301:	ATTHVGMEES EAAGLNSIFW GTFAACRGLA IFFATLLQPG TMMVLCNIGS LASSFFLVLF 
361:	DKSPLCLWIA SSVYGASMAA TFPSGISWIE QYTTLTGKSA AFILVGAALG LMATPALSGI 
421:	LQGHYPDLPV ILYMCLGSAV LTTVLFPVMY KVATLPLDRK QEKSINSEGQ KILLSSSRLI 
481:	KEAK