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2.A.1.81.1
The copper (Cu2+) uptake porter, CcoA of 405 aas and 12 TMSs. CcoA-mediated Cu2+ import relies on conserved Met and His residues that could act as metal ligands at the membrane-embedded Cu2+-binding domain (Khalfaoui-Hassani et al. 2016). It provides cytoplasmic Cu needed for cbb3-type cytochrome c oxidase (cbb3-Cox) biogenesis (Khalfaoui-Hassani et al. 2021). Residues important for and/or esstential for function have been identified. CcoA undergoes a thiol:disulfide oxidoreduction cycle, which is important for its Cu import activity (Khalfaoui-Hassani et al. 2021).

Accession Number:D5AKT2
Protein Name:Major facilitator superfamily MFS_1
Length:405
Molecular Weight:41647.00
Species:Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) [272942]
Number of TMSs:12
Substrate Copper 2+

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTQTAASAPP LPLRNLIVLV AAQAFLGAQM SMIFTVGGLA GQSLATNPCL ATLPLSLIVL 
61:	GSVLTAQPMS SFMAVYGRRA GFILATAAGG IGAAISAHAL AIGSFPLFCL GSLLAGIYMS 
121:	AQGFYRFAAT DGIAPEHQSK AISWVLAGGL AAAVLGPQLV KLTAQALVVP FQATYLAIIA 
181:	INLAGPLIFA FLRIPAPGRR VKGQAGGRTR GELLRDPVIL VAMICGMVSY ALMNLVMTST 
241:	PLAVVGCGHT TTNAADIVSA HVLAMYLPSF FTGHLIARFG RETIVGIGLF ILAVAGAVAL 
301:	TGVDLEQFFL ALMLLGLGWN FGFIGSTAML AAAHAPEERG TVQGMNDFVV FGGVFLASLS 
361:	SGGLMTCASA DAVAGWQAVN LAMLPFLTLA GAALIWLVLR PKDTR