2.A.106.1.5 Chloroplast thylakoid GDT-1-like protein or photosynthesis-affected protein-71, PAM71 or CCHA1 of 370 aas with 6 TMSs in a 3 + 3 TMS arrangement. It takes up Mn2+ and influences both Mn2+ and Ca2+ homeostasis in the chloroplast. It is necessary for photosystem II function due to its Mn2+ uptake activity (Schneider et al. 2016; Hoecker et al. 2017). It is an Mn2+/H+ exchanger, which transport Mn2+ from the chloroplast stroma into the acidic thylakoid lumen (Schneider et al. 2016). It might be a chloroplast-localized Ca2+/H+ antiporter as well (Wang et al. 2016) since it regulates Ca2+, Mn2+ and pH homeostasis and is required for chloroplast development.
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Accession Number: | Q94AX5 |
Protein Name: | GDT1-like protein 1, chloroplastic |
Length: | 370 |
Molecular Weight: | 39074.00 |
Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
Number of TMSs: | 7 |
Location1 / Topology2 / Orientation3: |
Plastid1 / Multi-pass membrane protein2 |
Substrate |
calcium(2+), hydron, manganese(2+) |
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1: MLSLNLSESL RIPFQNPRPP KSDFSSTSSS PSSSSRRCVS AYPIPIGFSV RNQYFSRCLT
61: QLRRNESQQL GFRCFQRNDA ACYLEKAESE EHDRNLDVLV ESSIAHSRRE IQRVLMFLAV
121: SGSVALLGTD PAFAASSIPN VTQSLVTSFG DLGDISSGFA SAFLLIFFSE LGDKTFFIAA
181: LLAARNSAAT VFVGTFGALG IMTIISVVLG RTFHYVDEVL PFRFGGTDLP IDDIAAVCLL
241: VYFGVSTLLD AVSDEGKADE EQKEAELAVS ELSGNGAGIV AAANTIISTF ALVFVAEWGD
301: KSFFSTIALA AASSPLGVIA GALAGHGAAT LLAVLGGSLL GNFLSEKAIA YVGGVLFLVF
361: AAVTVAEIVT