2.A.108.2.11
Putative heavy metal transporter, Ftr1/Tp34 or Tpd, (TP0972/TP0971). Ftr1 has 448 aas with 9 TMSs while Tp34 has 204 aas with 1 N-terminal TMSs. This antigen is a pathogen-specific membrane immunogen. This periplasmic dimeric protein binds human lactoferrin with submicromolar affinity with a stoichiometry of 2:1 (Deka et al. 2007). It's 3-d structure (1.9 Å resolution) reveals two metal binding sites per monomer with zinc bound to both sites (Deka et al. 2007).
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| Accession Number: | O83937 |
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| Protein Name: | Conserved hypothetical integral membrane protein |
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| Length: | 448 |
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| Molecular Weight: | 48456.00 |
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| Species: | Treponema pallidum (strain Nichols) [243276] |
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| Number of TMSs: | 9 |
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| Substrate |
metal cation |
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1: MERSWEGIDR GVPVYGMGCT MVAPGMPAAF ARSVVRASAW VGVALMCVAW SVSAAEGTRS
61: GGQAQERLSS WRQVVQRMEV HLRAAYTFFE SGDSDRAYEQ IDKAYFRYYE AKGMEKITMG
121: YLSGARKAAV ENAFFAYRRS VRGARDLAGV AFCRDKLVTM LYEDARALDG VARGRAGFAA
181: HIATFVASCV LVLREGIEAI LVIAAIVAYL VKTGKERCCA AVYAGAGAGV LFSVVLAVMI
241: VRVLGSEGGA AQEIIEGVGM FFAAAMLFYV SNWMLSKARA CAWDRYIRQK VERSVSRGNQ
301: WALVATAFLA VAREGAELIL FFRGIPVAGP YGRLAVWAAV TVSALVLVGV FVAIRFLSVR
361: LPLRPFFVAT GAVMYLLCFS FVGKGVSELQ EAGVVSRSTA PWMHGWSFDF LGIYPTYEGL
421: APQAFVVALV VLSAVWWCGG LCRGASST