2.A.109.1.7
Membrane protein induced over 100x by alkaline conditions, Alx or YgjT of 321 aas and 9 TMSs (Stancik et al. 2002). This riboswitch-controlled manganese exporter (Alx) tunes intracellular Mn2+ concentration in E. coli at alkaline pH. A set of acidic residues in the predicted TMSs of Alx play a role in Mn2+ export (Sharma and Mishanina 2023).
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| Accession Number: | P42601 |
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| Protein Name: | Inner membrane protein alx |
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| Length: | 321 |
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| Molecular Weight: | 35909.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 9 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MNTVGTPLLW GGFAVVVAIM LAIDLLLQGR RGAHAMTMKQ AAAWSLVWVT LSLLFNAAFW
61: WYLVQTEGRA VADPQALAFL TGYLIEKSLA VDNVFVWLML FSYFSVPAAL QRRVLVYGVL
121: GAIVLRTIMI FTGSWLISQF DWILYIFGAF LLFTGVKMAL AHEDESGIGD KPLVRWLRGH
181: LRMTDTIDNE HFFVRKNGLL YATPLMLVLI LVELSDVIFA VDSIPAIFAV TTDPFIVLTS
241: NLFAILGLRA MYFLLAGVAE RFSMLKYGLA VILVFIGIKM LIVDFYHIPI AVSLGVVFGI
301: LVMTFIINAW VNYRHDKQRG G