2.A.114.1.10
BtsT (from the German word for pyruvate: """"Brenztraubensäure"""" transporter) or YjiY of 716 aas and 18 TMSs. It is a high affinity (Km + 16 μM), inducible, specific pyruvate:proton uptake symporter (Kristoficova et al. 2017). Expression of the btsT (yjiY) gene is regulated by the LytS-like
histidine kinase, BtsS, a sensor of extracellular pyruvate, together with
the LytTR-like response regulator, BtsR (Kristoficova et al. 2017).It may also mediate uptake of specific peptides, thus initiating their metabolism, but this has not been demonstrated directly. It indirectly influences flagellar biosynthesis and virulence. BtsT (YjiY) is required for successful colonization of Salmonella in the mouse gut (Garai et al. 2015). It also influences expression of the mgtC gene to regulate biofilm formation (Garai et al. 2017).
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| Accession Number: | Q8ZJY5 |
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| Protein Name: | Putative carbon starvation protein |
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| Length: | 716 |
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| Molecular Weight: | 77346.00 |
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| Species: | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) [99287] |
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| Number of TMSs: | 16 |
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| Substrate |
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1: MDTKKIFKHI PWVILGIIGA FCLSVVALRR GEHVSALWIV VASVSVYLVA YRYYSLYIAQ
61: KVMKLDPTRA TPAVINNDGL NYVPTNRYVL FGHHFAAIAG AGPLVGPVLA AQMGYLPGTL
121: WLLAGVVLAG AVQDFMVLFI SSRRNGASLG EMIKEEMGTV PGTIALFGCF LIMIIILAVL
181: ALIVVKALAE SPWGVFTVCS TVPIALFMGI YMRFLRPGRV GEVSVIGIVL LVASIYFGGV
241: IAHDPYWGPA LTFKDTTITF ALIGYAFVSA LLPVWLILAP RDYLATFLKI GVIVGLALGI
301: VILNPELKMP ALTQYVDGTG PLWKGALFPF LFITIACGAV SGFHALISSG TTPKLLACET
361: DARFIGYGAM LMESFVAVMA LVAASIIEPG LYFAMNTPPA GLGITMPNLH EMGGENAPLI
421: MAQLKDVTAH AAATVSSWGF VISPEQILQT AKDIGEPSVL NRAGGAPTLA VGIAHVFHKV
481: LPMADMGFWY HFGILFEALF ILTALDAGTR SGRFMLQDLL GNFVPFLKKT DSLVAGIIGT
541: AGCVGLWGYL LYQGVVDPLG GVKSLWPLFG ISNQMLAAVA LVLSTVVLIK MQRTKYIWVT
601: VIPAVWLLIC TTWALGLKLF SANPQMEGFF YMANLYKEKI ANGANLTEQQ IANMNHIVVN
661: NYTNAGLSIL FLVVVYSIIF YGFTTWMKVR NSDKRTDKET PYVPVPEGGV KISSHH