2.A.117.1.3
Chlorhexidine-responsive putative chlorhxidine exporter of 160 aas and 4 TMSs, AceI (Hassan et al. 2013). It confers resistance to both proflavine and acriflavine by an active efflux mechanism (Hassan et al. 2015). AceR is an activator of aceI gene expression when challenged with chlorhexidine (Liu et al. 2018). This system also exports polyamines (organic diamines) such as cadaverine and putrescine (and possibly spermidine with low affinity).  It is induced preferentially by cadaverine and putrescine, and to a much lesser extent by spermidine. An AceI-E15Q mutant is inactive (Hassan et al. 2019).