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2.A.118 The Basic Amino Acid Antiporter (ArcD) Family

The ArcD family is a constituent of the IT superfamily (Lolkema and Slotboom, 2003; Prakash et al., 2003; Rabus et al., 1999). It is the st313/AitC family of Lolkema and Slotboom (2003). It consists of proteins from Gram-negative and Gram-positive bacteria (e.g., Streptococcus, Escherichia, Salmonella, Fusobacterium and Borrelia species). The proteins are of about 480 aas with 10-12 putative TMSs. Functionally characterized homologues are in the DcuC (TC #2.A.61) and ArsB (TC #2.A.4) families. Some members of the family probably catalyze arginine/ornithine or citruline/ornithine antiport (Gupta et al., 2013; Rimaux et al., 2013).

This family belongs to the: IT Superfamily.

References associated with 2.A.118 family:

Gupta, R., J. Yang, Y. Dong, E. Swiatlo, J.R. Zhang, D.W. Metzger, and G. Bai. (2013). Deletion of arcD in Streptococcus pneumoniae D39 impairs its capsule and attenuates virulence. Infect. Immun. 81: 3903-3911. 23918778
Lolkema, J.S. and D.J. Slotboom. (2003). Classification of 29 families of secondary transport proteins into a single structural class using hydropathy profile analysis. J. Mol. Biol. 327: 901-909. 12662917
Prakash, S., G. Cooper, S. Singhi, and M.H. Saier, Jr. (2003). The ion transporter superfamily. Biochim. Biophys. Acta. 1618: 79-92. 14643936
Rabus, R., D.L. Jack, D.J. Kelly, and M.H. Saier, Jr. (1999). TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology 145(Pt12): 3431-3445. 10627041
Rimaux, T., A. Rivière, E.M. Hebert, F. Mozzi, S. Weckx, L. De Vuyst, and F. Leroy. (2013). A putative transport protein is involved in citrulline excretion and re-uptake during arginine deiminase pathway activity by Lactobacillus sakei. Res. Microbiol. 164: 216-225. 23178175
Wang, X., Y. Xie, P. Gao, S. Zhang, H. Tan, F. Yang, R. Lian, J. Tian, and G. Xu. (2014). A metabolomics-based method for studying the effect of yfcC gene in Escherichia coli on metabolism. Anal Biochem 451: 48-55. 24513124