TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.120.1.1









Putative permease of 349 aas

Bacteria
Bacillota
PP of Staphylococcus epidermidis
2.A.120.1.2









Putative permease of 372 aas

Bacteria
Bacillota
PP of Coprococcus catus
2.A.120.1.3









Putative permease of 496 aas

Bacteria
Bacillota
PP of Clostridium botulinum
2.A.120.1.4









Putative permease of 378 aas

Bacteria
Pseudomonadota
PP of Sphingopyxis alaskensis
2.A.120.1.5









Putative permease of 378 aas

Archaea
Euryarchaeota
PP of Pyrococcus horikoshii
2.A.120.1.6









Putative permease of 326 aas

Bacteria
Bacillota
PP of Caldicellulosiruptor kristjanssonii
2.A.120.1.7









Putative permease of 358 aas

Bacteria
Bacillota
PP of Desulfotomaculum acetoxidans
2.A.120.1.8









Putative permease of 355 aas, ProT.  It is 71% identical to the S. aureus ortholog, ProT (TC# 2.A.120.1.14), which has been shown to be the major proliine uptake transporter in S. aureus and is essential for infections in skin and soft tissues when external proline is provided as a source of this amino acid in minimal growth media (Lehman et al. 2023).

Bacteria
Bacillota
ProT of Staphylococcus carnosus
2.A.120.1.9









Putative amino acid transporter, YyaD, which possibly plays a role in sporulation.

Bacteria
Bacillota
YyaD of Bacillus subtilis
2.A.120.1.10









Putative amino acid transporter, YkvI

Bacteria
Bacillota
YkvI of Bacillus subtilis
2.A.120.1.11









Putative amino acid uptake porter of 700 aas, BrkK, with a C-terminal Lactamase B domain.

Bacteria
Bacillota
BrkK of Eubacterium brachy
2.A.120.1.12









Putative alanine:sodium symporter

Bacteria
Bacillota
Putative transporter of Mogibacterium sp.
2.A.120.1.13









Uncharacterized protein

Archaea
Thermoproteota
UP of Caldivirga maquilingensis
2.A.120.1.14









Proline transporter, ProT, of 355 aas and 10 TMSs in a 2 + 3 + 2 + 3 TMS arrangement.  It is a major proline uptake transporter in S. aureus and is required for infection in skin and soft tissues. In minimal medium it is the major proline uptake porter (Lehman et al. 2023). Its ortholog in S. carnosis (TC# 2.A.120.1.8) is 71% identical to this protein.

Bacteria
Bacillota
ProT of Staphylococcus aureus