2.A.120.1.14
Proline transporter, ProT, of 355 aas and 10 TMSs in a 2 + 3 + 2 + 3 TMS arrangement. It is a major proline uptake transporter in S. aureus and is required for infection in skin and soft tissues. In minimal medium it is the major proline uptake porter (Lehman et al. 2023). Its ortholog in S. carnosis (TC# 2.A.120.1.8) is 71% identical to this protein.
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| Accession Number: | ARG45194 |
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| Protein Name: | ARG45194.1 hypothetical protein B7H15_03660 [Staphylococcus aureus] |
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| Length: | 356 |
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| Molecular Weight: | |
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| Species: | Staphylococcus aureus [1280] |
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| Number of TMSs: | 10 |
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| Substrate |
L-proline |
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1: MMMNKEATKI GFAYVGIVVG AGFSTGQEVM QFFTKYGLWA YLGVIISGFI LAFIGRQVAK
61: IGTAFEATNH ESTLQYVFGE KFSKVFDYIL IFFLFGIAVT MIAGAGATFE ESYNIPTWLG
121: ALIMTLAIYI TLLLDFNKIV RALGIVTPFL IVLVVLIAGV YLFKGHVSLA EVNQVVPEAS
181: IWKGIWFGTI YGGLAFSVGF STIVAIGGDT EKRTVSGAGA MYGGIIYTVL LALINFALQS
241: EYPTIKNASI PTLTLANNIH PLIATVLSVI MLAVMYNTIL GLMYSFAARF TEPYSKNYHI
301: FIIIMMVAGY LLSFVGFAEL INKLYTIMGY VGLFIVVAVI IKYFKRKNAD KKHIA