2.A.123.1.9
Sweet1: bidirectional low affinity glucose uniporter, Km = ~9 mM (Does not transport mannose, fructose or galactose) (Chen et al. 2010). The structure is know, and three regions, each containing several well conserved essential residues, comprise the substrate-binding pocket, the extrafacial gate, and the intrafacial gate (Xuan et al. 2013; Tao et al. 2015). The orthologous SWEET1 in Camellia sinensis (tea) transports glucose, glucose analogues, and other hexoses (Wang et al. 2018).
|
| Accession Number: | Q8L9J7 |
|---|
| Protein Name: | Bidirectional sugar transporter SWEET1 |
|---|
| Length: | 247 |
|---|
| Molecular Weight: | 27268.00 |
|---|
| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
|---|
| Number of TMSs: | 7 |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
maltose, glucose |
|---|
| Entrez Gene ID: |
838744
|
|---|
| Pfam: |
PF03083
|
|---|
| KEGG: |
ath:AT1G21460
|
|---|
|
|
[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.” Theologis A. et.al. 11130712
[2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.” Yamada K. et.al. 14593172
[3] “Sugar transporters for intercellular exchange and nutrition of pathogens.” Chen L.-Q. et.al. 21107422
|
1: MNIAHTIFGV FGNATALFLF LAPSITFKRI IKNKSTEQFS GIPYPMTLLN CLLSAWYGLP
61: FVSKDNTLVS TINGTGAVIE TVYVLIFLFY APKKEKIKIF GIFSCVLAVF ATVALVSLFA
121: LQGNGRKLFC GLAATVFSII MYASPLSIMR LVVKTKSVEF MPFFLSLFVF LCGTSWFVYG
181: LIGRDPFVAI PNGFGCALGT LQLILYFIYC GNKGEKSADA QKDEKSVEMK DDEKKQNVVN
241: GKQDLQV