2.A.125.1.1
The riboflavin (Km = 40μM) transporter, RFT1, SLC52A1, of 448 aas and 11 TMSs in a 6 + 5 TMS arrangement (Yonezawa et al. 2008). The C-terminal 150 aas are 92% identical to porcine endogenous retrovirus A receptor 2 (PERV-A receptor 2) and 57% identical to the G-protein-coupled receptor 172A (XP_001519123).
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| Accession Number: | B5MEV1 |
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| Protein Name: | Riboflavin transporter 1 |
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| Length: | 448 |
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| Molecular Weight: | 46373.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Cell outer membrane1 / Peripheral membrane protein2 |
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| Substrate |
riboflavin |
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| Pfam: |
PF06237
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[1] “Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1.” Yonezawa A. et.al. 18632736
[2] “The sequence of the human genome.” Venter J.C. et.al. 11181995
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1: MAAPTLGRLV LTHLLVALFG MGSWAAVNGI WVELPVVVKD LPEGWSLPSY LSVVVALGNL
61: GLLVVTLWRR LAPGKGEQVP IQVVQVLSVV GTALLAPLWH HVAPVAGQLH SVAFLTLALV
121: LAMACCTSNV TFLPFLSHLP PPFLRSFFLG QGLSALLPCV LALVQGVGRL ECPPAPTNGT
181: SGPPLDFPER FPASTFFWAL TALLVTSAAA FRGLLLLLPS LPSVTTGGSG PELQLGSPGA
241: EEEEKEEEEA LPLQEPPSQA AGTIPGPDPE VHQLFSAHGA FLLGLMAFTS AVTNGVLPSV
301: QSFSCLPYGR LAYHLAVVLG SAANPLACFL AMGVLCRSLA GLVGLSLLGM LFGAYLMALA
361: ILSPCPPLVG TTAGVVLVVL SWVLCLCVFS YVKVAASSLL HGGGRPALLA AGVAIQVGSL
421: LGAGAMFPPT SIYHVFQSRK DCVDPCGP