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TCIDNameDomainKingdom/PhylumProtein(s)
2.A.130.1.1









The Type IX protein secretory system (T9SS) of about 15 components (Lauber et al. 2018).  See the family description for details, and the examples cited below for the characteristics and functions, when known, for the 15 potential constituents, which are listed with functional information in the left hand column of this entry (McBride and Zhu 2013). Veith et al. 2017 and Paillat et al. 2023 have reviewed these T9SSs, and have described 18 (or 19) constituents including regulatory proteins.  See the family description and PaillatLauber et al. 2018).  See the family description for details, and the examples cited below for the characteristics and functions, when known, for the 15 potential constituents, which are listed with functional information in the left hand column of this entry (McBride and Zhu 2013). Veith et al. 2017 and Paillat et al. 2023 have reviewed these T9SSs, and have described 18 (or 19) constituents including regulatory proteins.  See the family description and Paillat et al. 2023 for details and potential functions and roles.

Bacteria
 Bacteroidota
T9SS of Porphyromonas gingivalis       
SprA, Sov, 2316 aas, forms a 32 stranded β-barrel and is likely to be the channel for the folded protein substrates. Q7MW38
Uncharacterized 8 stranded OM β-barrel protein of 235 aas; associated with PorK and PorN. Q7MXJ5
Putative OM lipoprotein of 827 aas. Multiple copies in some bacteria. Q7MWR1
Predicted TonB-dependent receptor; lipoprotein of 491 aas. Q7MXB7
PorK, GldK, OM lipoprotein of 346 aas. Forms large periplasmic rings with PorN. Q7MXB6
PorL, GldL, IM protein of 516 aas and 2 TMSs. Interacts with PorM and PorX. Q7MXB5
PorM, GldM, IM protein of 361 aas with periplasmic domains. Interacts with PorL, PorK and PlrN. Q7MXB4
PorN, GldN, forms large periplasmic rings with PorK. B2RLE7
GldO, Paralog of PorN; not present in P gingivalis. Both GldN and GldO need to be disrupted to cause loss of motility in F. johnsoniae. Q7MXB8
PorP, SprF, SprP, predicted OM β-barrel protein of 346 aas with multiple copies in some bacteria. Q7MWK8
PorQ, predicted 14 stranded OM β-barrel protein of193 aas, like FadL. Binds PorZ. Q7MXL2
PorT, SprT, predicted 8 stranded OM β-barrel protein of 1123 aas. Q7MXX2
PorU, Predicted C25 protease (gingipain) of 391 aas.  Contains an uncleaved T9SS signal.  May be the T9SS sortase. Binds PorV. Q7MXX1
PorV, LptO, Predicted 14 stranded OM β-barrel protein of 1160 aas; like FadL.  Binds T9SS substrates including PorU.  May be a shuttle protein.
PorW, SprE, predicted lipoprotein with TPR repeats, of 518 aas. Q7MVV4
2.A.130.1.2









The Type IX secretion system (T9SS) with ~20 putative components, SprA, SprE, SprT, GldK, GldL, GldM, GldN, SprC, SprD, GldB, GldD, GldH, GldI, GldJ, GldA, GldF, GldG, PorV, PorU, and PorZ.  The pmf-driven motor (the proton channel) may consist of GldL (like MotA; TC# 2.A.130.1.2) and GldM (like MotB) (Paillat et al. 2023).

Bacteria
 Bacteroidota
About 20 components of the T9SS/gliding motility system of Flavobacterium johnsoniae (Cytophaga johnsoniae).
GldK (464 aas; 1TMS, N-erminal) (Q5EGM5)
GldL (215 aas; 2TMSs, N-terminal) (Q5EGM4)
GldM; GldR1 (513 aas; 1TMS) (Q5EGM3)
SprA (2,403 aas; 1TMS) (Q5I6C7)
SprE (870 aas; 1TMS) (A1E5T9)
SprT (237 aas; 1TMS) (A5FJX0)
SprC (483 aas; A1E5U3)
SprD (1588 aas; A1E5U4)
GldB (318 aas; lipoportein; Q9WWY2)
GldD (186 aas; Q9EZL6)
GldH (159 aas; lipoprotein; Q8KRP0)
GldI (218 aas; peptidyl-prolyl cis-trans isomerase; Q8KRN4)
GldJ (428 aas; Q8KRM8)
GldN (329 aas; Q5EGM2)
GldA (298 aas; O30489)
GldF (241 aas; Q93LN1)
GldG (561 aas; Q93LN0)
PorV (327 aas; A5FN94)
PorU (1,278 aas; sortase; WJS96258.1)
PorZ 760 aas; periplasmic ligand-binding sensor protein; A5FM32)