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TCID	Name	Domain	Kingdom/Phylum	Protein(s)
2.A.16.1.1	Tellurite resistance protein, TehA. Encoded in an operon with the gene for a tellurite S-adenosylmethionine-dependent methyl transferase. Together they confer tellurite resistance (Moraes and Reithmeier 2012). High level cell-free expression and specific labeling of TehA from E. coli has been achieved (Klammt et al. 2004).	Bacteria	Pseudomonadota	TehA of E. coli
2.A.16.1.2	Tellurite resistance protein TehA homologue of 328 aas and 10 TMSs. An anion channel involved in tellurite resistance. A quasi-symmetrical homotrimer in which each subunit has 10 TMSs and forms a channel. The crystal structure is known at 1.2 A resolution (Chen et al. 2010). The helices are arranged from helical hairpin pairs to form a central 5-helix transmembrane pore that is gated by a conserved phenylalanine residue. Gating is controlled by kinase activation. Selectivity for various anions may be a function of the energetic cost of ion dehydration (Chen et al. 2010). High level cell-free expression and specific labeling of TehA from E. coli has been achieved (Klammt et al. 2004).	Bacteria	Pseudomonadota	Tellurite resistance protein TehA homologue of Haemophilus influenzae
2.A.16.2.1	Mae1 malate:proton symport protein. May also transport other dicarboxylates such as oxaloacetate, malonate, succinate and fumarate (Camarasa et al. 2001). May also transport thio-malate (Osawa and Matsumoto 2006).	Eukaryota	Fungi, Ascomycota	Mae1 of Schizosaccharomyces pombe
2.A.16.2.2	The ATP-dependent subtelomeric helicase, RecQ (2100 aas with a 5 TMS N-terminal domain (residues 43-210). 94% identical to 2.A.16.2.1 (malate transporter) of the same species.	Eukaryota	Fungi, Ascomycota	RecQ of Schizosaccharomyces pombe (Q5EAK4)
2.A.16.2.3	C4-dicarboxylate transporter/malic acid transport protein, Mae1 of 395 aas and 10 TMSs. It has been overexpressed for the production of L-malate (Liu et al. 2017).	Eukaryota	Fungi, Ascomycota	Mae1 of Emericella nidulans (Aspergillus nidulans)
2.A.16.3.1	The sulfite efflux (sulfite sensitivity) protein, SSU1. Expression is controlled by the FZF1-4 transcriptional activator; only free sulfite (not complexed sulfite) is exported (Park and Bakalinsky, 2000). Can also export nitrite and nitrate (Cabrera et al. 2014). SSU1 has a putative 10 TMS topology in a (S-L)₅ arrangement where S= a small putative TMS and L= a large TMS.	Eukaryota	Fungi, Ascomycota	SSU1 of Saccharomyces cerevisiae (P41930)
2.A.16.3.2	Sulfite, nitrate exporter of 384 aas, Ssu1 (Cabrera et al. 2014).	Eukaryota	Fungi, Ascomycota	Ssu1 of Pichia angusta (Yeast) (Hansenula polymorpha)
2.A.16.3.3	Sulfite/nitrate exporter of 392 aas, Ssu2 (Cabrera et al. 2014).	Eukaryota	Fungi, Ascomycota	Ssu2 of Pichia angusta (Yeast) (Hansenula polymorpha)
2.A.16.4.1	The unknown homologue, UnkH (same topology as 2.A.16.3.1)	Eukaryota	Fungi, Ascomycota	UnkH of Aspergillus niger (A2QYD7)
2.A.16.4.2	Sulfite efflux pump, Ssul (Sulfite sensitivity protein) (Lechenne et al., 2007).	Eukaryota	Fungi, Ascomycota	Ssul of Arthroderma benhamiea (A3R044)
2.A.16.4.3	Sulfite efflux pump, Ssul (Lechenne et al., 2007).	Eukaryota	Fungi	Ssul of Aspergillus fumigatus (Q2TJJ2)
2.A.16.4.4	Uncharacterized transporter MJ0762	Archaea	Euryarchaeota	MJ0762 of Methanocaldococcus jannaschii
2.A.16.4.5	TDT homolouge	Archaea	Thermoproteota	TDT homologue of Sulfolobus acidocaldarius
2.A.16.4.6	TDT homologue	Bacteria	Actinomycetota	TDT homologue of Streptomyces coelicolor
2.A.16.5.1	The plant guard cell S (Slow)-type anion channel, SLAC1 (based on activation kinetics of anion channel currents in response to voltage changes); functions in stomatal signalling, controls turgor pressure, and regulates the exchange of water and CO₂ (Chen et al. 2010). Also called carbon dioxide insensitive (CDI3) and ozone sensitive (OZS1) (Kollist et al., 2011). Heterotrimeric G proteins regulate guard cell ion channels (Zhang, 2011). Evolutionary studies have been reported (Dreyer et al. 2012). The transmembrane region of guard cell SLAC1 channels detect CO₂ signals via an abscisic acid (ABA)-independent pathway (Yamamoto et al. 2016). SLAC1 is activated by the protein kinase OST1 (OPEN STOMATA 1), the Ca²⁺-dependent protein kinases (CPKs), the GHR1 (GUARD CELL HYDROGEN PEROXIDE-RESISTANT 1) transmembrane receptor-like protein (TC# 1.A.87.2.8), or the PYL5 abscisic acid (ABA) receptor (Q9FLB1) (Wang et al. 2017). The structure of SLAC1 in an inactivated, closed state has been determined (Li et al. 2022). The cytosolic N-terminus and C-terminus are partially resolved and form a plug-like structure which packs against the TM domain. Breaking the interactions between the cytosolic plug and the TMD triggers channel activation. An inhibition-release model is proposed for SLAC1 activation by phosphorylation, that the cytosolic plug dissociates from the TMD upon phosphorylation, and induces conformational changes to open the pore. These findings facilitate an understanding of the regulation of SLAC1 activity and stomatal aperture in plants (Li et al. 2022).	Eukaryota	Viridiplantae, Streptophyta	SLAC1 of Arabidopsis thaliana (Q9LD83)
2.A.16.5.2	Slow anion channel homologue-3, SLAH3; nitrate is both a substrate and a gate opener (Geiger et al. 2011). Slow, weak voltage-dependent S-type anion efflux channel involved in maintenance of anion homeostasis (Negi et al. 2008). Binds to the highly selective inward-rectifying potassium channel KAT1 and inhibits its activity. Functions as an essential negative regulator of inward potassium channels in guard cells. Essential for the efficient stomatal closure and opening in guard cells (Zhang et al. 2016). The plasma membrane Glycine soja (soy bean) GsSLAH3 protein contains ten TMSs. GsSLAH3 expression is induced by NaHCO₃ treatment, suggesting an involvement to alkaline stress, and ectopic expression of GsSLAH3 in yeast increased sensitivity to alkali treatment (Duan et al. 2017). Overexpression of GsSLAH3 in Arabidopsis thaliana enhanced alkaline tolerance during germination, seedling and adult stages. Transgenic lines improved plant tolerance to KHCO₃ rather than high pH treatment. Overexpressing lines accumulated more NO3^- than wild type (Duan et al. 2017).	Eukaryota	Viridiplantae, Streptophyta	SLAH3 of Arabidopsis thaliana
2.A.16.5.3	SLAC1/SLAH nitrate transporter (slow anion channel-associated homologue) of 565 aas and 12 TMSs in a 6 + 6 TMS arrangement. This protein was identified and partially characterized in wheat (Kumar et al. 2022). Increased transmembrane transport of per- and polyfluoroalkyl substances (PFASs), stimulated by humic acid (HA) is mainly driven by the slow-type anion channel pathways interacting with Ca²⁺-dependent protein kinases (Ca²⁺-CDPK-SLAC1). The promoted transmembrane transport of PFASs might cause adverse effects on the plant cell wall (Liu et al. 2023).	Eukaryota	Viridiplantae, Streptophyta	SLAC1/SLAH of Triticum aestivum
2.A.16.6.1	TDT homologue, TehA of 302aas and 10 TMSs	Bacteria	Bacillota	TehA of Streptococcus pyogenes (Q9A061)
2.A.16.6.2	TehA homologue of 314aas and 10 TMSs	Bacteria	Bacillota	TehA of Clostridium butyricum (C4IKV8)
2.A.16.6.3	Uncharacterized protein of 332 aas and 10 TMSs.	Bacteria	Bacillota	UP of Lactobacillus dextrinicus