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2.A.17.1.2 The di/tripeptide:H⁺ symport permease, TppB (DtpA or YdgR) (transports di and tripeptides and peptidomimetics such as aminocephalosporins (Weitz et al., 2007). The transporter has two alternate conformations, one of which is promoted by inhbitor binding (Bippes et al. 2013).
Accession Number:	P77304
Protein Name:	tppB
Length:	500
Molecular Weight:	53991.00
Species:	Escherichia coli (strain K12) [83333]
Number of TMSs:	14
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	hydron, tripeptide, dipeptide, 7beta-aminocephalosporanic acid

Structure:
RefSeq:	AP_002256.1 NP_416151.1
Entrez Gene ID:	947436
Pfam:	PF00854
BioCyc:	EcoCyc:B1634-MONOMER ECOL168927:B1634-MONOMER
KEGG:	ecj:JW1626 eco:b1634
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0042936 F:dipeptide transporter activity GO:0015333 F:peptide:hydrogen symporter activity GO:0042937 F:tripeptide transporter activity GO:0042938 P:dipeptide transport GO:0015031 P:protein transport GO:0042939 P:tripeptide transport
References (6) [1] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.” Aiba H.et.al. 9097039 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “The Escherichia coli tppB (ydgR) gene represents a new class of OmpR-regulated genes.” Goh E.B.et.al. 15175316 [5] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996 [6] “Functional and structural characterization of a prokaryotic peptide transporter with features similar to mammalian PEPT1.” Weitz D.et.al. 17158458
6GS1 6GS4 6GS7

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSTANQKPTE SVSLNAFKQP KAFYLIFSIE LWERFGYYGL QGIMAVYLVK QLGMSEADSI 
61:	TLFSSFSALV YGLVAIGGWL GDKVLGTKRV IMLGAIVLAI GYALVAWSGH DAGIVYMGMA 
121:	AIAVGNGLFK ANPSSLLSTC YEKNDPRLDG AFTMYYMSVN IGSFFSMIAT PWLAAKYGWS 
181:	VAFALSVVGL LITIVNFAFC QRWVKQYGSK PDFEPINYRN LLLTIIGVVA LIAIATWLLH 
241:	NQEVARMALG VVAFGIVVIF GKEAFAMKGA ARRKMIVAFI LMLEAIIFFV LYSQMPTSLN 
301:	FFAIRNVEHS ILGLAVEPEQ YQALNPFWII IGSPILAAIY NKMGDTLPMP TKFAIGMVMC 
361:	SGAFLILPLG AKFASDAGIV SVSWLVASYG LQSIGELMIS GLGLAMVAQL VPQRLMGFIM 
421:	GSWFLTTAGA NLIGGYVAGM MAVPDNVTDP LMSLEVYGRV FLQIGVATAV IAVLMLLTAP 
481:	KLHRMTQDDA ADKAAKAAVA

2.A.17.1.2
The di/tripeptide:H⁺ symport permease, TppB (DtpA or YdgR) (transports di and tripeptides and peptidomimetics such as aminocephalosporins (Weitz et al., 2007). The transporter has two alternate conformations, one of which is promoted by inhbitor binding (Bippes et al. 2013).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.17.1.2The di/tripeptide:H+ symport permease, TppB (DtpA or YdgR) (transports di and tripeptides and peptidomimetics such as aminocephalosporins (Weitz et al., 2007). The transporter has two alternate conformations, one of which is promoted by inhbitor binding (Bippes et al. 2013).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.17.1.2
The di/tripeptide:H⁺ symport permease, TppB (DtpA or YdgR) (transports di and tripeptides and peptidomimetics such as aminocephalosporins (Weitz et al., 2007). The transporter has two alternate conformations, one of which is promoted by inhbitor binding (Bippes et al. 2013).