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2.A.17.1.3 The dipeptide/tripeptide:H⁺ symport permease, DtpB (YhiP) (transports glycyl-sarcosine (Gly-Sar) with low affinity (6mM) and the toxic dipeptide, alafosfalin (Harder et al., 2008)
Accession Number:	P36837
Protein Name:	DtpB
Length:	489
Molecular Weight:	53575.00
Species:	Escherichia coli (strain K12) [83333]
Number of TMSs:	14
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	hydron, tripeptide, dipeptide

DIP:	DIP-12369N
RefSeq:	AP_004297.1 NP_417953.1
Entrez Gene ID:	948006
Pfam:	PF00854
BioCyc:	EcoCyc:YHIP-MONOMER ECOL168927:B3496-MONOMER
KEGG:	ecj:JW3463 eco:b3496
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0042936 F:dipeptide transporter activity GO:0015293 F:symporter activity GO:0042937 F:tripeptide transporter activity GO:0042938 P:dipeptide transport GO:0042939 P:tripeptide transport
References (4) [1] “Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes.” Sofia H.J.et.al. 8041620 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MNTTTPMGML QQPRPFFMIF FVELWERFGY YGVQGVLAVF FVKQLGFSQE QAFVTFGAFA 
61:	ALVYGLISIG GYVGDHLLGT KRTIVLGALV LAIGYFMTGM SLLKPDLIFI ALGTIAVGNG 
121:	LFKANPASLL SKCYPPKDPR LDGAFTLFYM SINIGSLIAL SLAPVIADRF GYSVTYNLCG 
181:	AGLIIALLVY IACRGMVKDI GSEPDFRPMS FSKLLYVLLG SVVMIFVCAW LMHNVEVANL 
241:	VLIVLSIVVT IIFFRQAFKL DKTGRNKMFV AFVLMLEAVV FYILYAQMPT SLNFFAINNV 
301:	HHEILGFSIN PVSFQALNPF WVVLASPILA GIYTHLGNKG KDLSMPMKFT LGMFMCSLGF 
361:	LTAAAAGMWF ADAQGLTSPW FIVLVYLFQS LGELFISALG LAMIAALVPQ HLMGFILGMW 
421:	FLTQAAAFLL GGYVATFTAV PDNITDPLET LPVYTNVFGK IGLVTLGVAV VMLLMVPWLK 
481:	RMIATPESH

2.A.17.1.3
The dipeptide/tripeptide:H⁺ symport permease, DtpB (YhiP) (transports glycyl-sarcosine (Gly-Sar) with low affinity (6mM) and the toxic dipeptide, alafosfalin (Harder et al., 2008)

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.17.1.3The dipeptide/tripeptide:H+ symport permease, DtpB (YhiP) (transports glycyl-sarcosine (Gly-Sar) with low affinity (6mM) and the toxic dipeptide, alafosfalin (Harder et al., 2008)

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.17.1.3
The dipeptide/tripeptide:H⁺ symport permease, DtpB (YhiP) (transports glycyl-sarcosine (Gly-Sar) with low affinity (6mM) and the toxic dipeptide, alafosfalin (Harder et al., 2008)