2.A.17.1.7 Peptide uptake transporter of 496 aas, POT. The 3-d structure has been determined to 1.9Å resolution leading to a proposed mechanism (Doki et al. 2013). Glu310 first may bind the carboxyl group of the peptide substrate. Then
deprotonation of Glu310 in the inward open state triggers the release of
the bound peptide toward the intracellular space, and salt bridge
formation between Glu310 and Arg43 induces the transition state to the
occluded conformation.
|
Accession Number: | Q5KYD1 |
Protein Name: | Di-tripeptide ABC transporter (Permease) |
Length: | 496 |
Molecular Weight: | 53457.00 |
Species: | Geobacillus kaustophilus (strain HTA426) [235909] |
Number of TMSs: | 14 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
peptide |
---|
1: MASIDKQQIA ASVPQRGFFG HPKGLFTLFF TEFWERFSYY GMRAILVYYM YYEVSKGGLG
61: LDEHLALAIM SIYGALVYMS GIIGGWLADR VFGTSRAVFY GGLLIMAGHI ALAIPGGVAA
121: LFVSMALIVL GTGLLKPNVS SIVGDMYKPG DDRRDAGFSI FYMGINLGAF LAPLVVGTAG
181: MKYNFHLGFG LAAVGMFLGL VVFVATRKKN LGLAGTYVPN PLTPAEKKKA AAIMAVGAVV
241: IAVLLAILIP NGWFTVETFI SLVGILGIII PIIYFVVMYR SPKTTAEERS RVIAYIPLFV
301: ASAMFWAIQE QGSTILANYA DKRTQLDVAG IHLSPAWFQS LNPLFIIILA PVFAWMWVKL
361: GKRQPTIPQK FALGLLFAGL SFIVILVPGH LSGGGLVHPI WLVLSYFIVV LGELCLSPVG
421: LSATTKLAPA AFSAQTMSLW FLSNAAAQAI NAQLVRFYTP ENETAYFGTI GGAALVLGLI
481: LLAIAPRIGR LMKGIR