2.A.17.1.8
Proton-coupled oligopeptide uptake transporter of 485 aas and 14 TMSs, DtpT or Pot. Expression of the encoded gene is upregulated upon infection. Transports di- and tripeptides but can not accumulate peptides with a positively charged residue in the C-terminal position. An aromatic residue patch in the active site of the transporter may be responsible for it's unusual specificity (Sharma et al. 2016).
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| Accession Number: | Q9JXB5 |
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| Protein Name: | Peptide transporter |
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| Length: | 485 |
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| Molecular Weight: | 52423.00 |
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| Species: | Neisseria meningitidis serogroup B (strain MC58) [122586] |
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| Number of TMSs: | 14 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
peptide |
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1: MSRHPAPTGE KTFFGHPFQL STLFHIELWE RFSFYGMQGI LLIYLYYTAD KGGLGIDKTL
61: AGGIVGAYSG SVYLSTILGA WFADRVWGAE KTLFLSGIVV MLGHIVLAAA PGLYGLLIGL
121: IFIALGSGGV KSTASSMVGA LYEQDEMRPL RDAGFSIFYI AINIGGFLGP LLTGLLQENI
181: GFHYGFGAAA VGMAFGLWRY SLGRKNLPHP TVPHPLSKGQ GKTAAAVGIA LIAALATAIK
241: TGLVNLDNFS GILLSTVILA VIAYFARLLT NPRVSSDNKR HIIAYIPLFL TICMFWAVWF
301: QIYTVATVYF DETVNRTIGS FTVPVAWKDS MQSLWVILFS GLMAAMWTKM GRKQPKTPLK
361: FAMAVFVTGA SFLGFVPFIS SGTPMPIAVF ALIVLAITIG ELMISPIALS ISTKIAPPLF
421: KTQMVALNFL AFSLGFTLGG VLFEKGYQAG DEIGFYRLLF YIGAATGFLL LLLVPKLNKM
481: LEGTD