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2.A.17.3.16
Nitrate transporter 1.2 (Nitrate transporter NTL1; NRT1:2; PRT family protein 4.6; NPF4.6; AIT1).  Low-affinity proton-dependent nitrate transporter involved in constitutive nitrate uptake but not histidine or dipeptides transport. Involved in (+)-abscisic acid (ABA) transport, but not in gibberellin, indole-3-acetic acid or jasmonic acid import; ABA and nitrate do not compete for substrate uptake (Kanno et al. 2013). Arabidopsis NPF4.6 and NPF5.1 control the leaf stomatal aperture by regulating abscisic acid transport (Shimizu et al. 2021). NPF4.6 is expressed in vascular tissues and guard cells, and it positively regulates stomatal closure in leaves (Shimizu et al. 2021).

Accession Number:Q8H157
Protein Name:Nitrate transporter 1.2
Length:585
Molecular Weight:63982.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate nitrate, (+)-abscisic acid

Cross database links:

Entrez Gene ID: 843321   
Pfam: PF00854   
KEGG: ath:AT1G69850   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015293 F:symporter activity
GO:0042128 P:nitrate assimilation
GO:0006857 P:oligopeptide transport
GO:0009624 P:response to nematode

References (7)

[1] “Cloning and functional characterization of an Arabidopsis nitrate transporter gene that encodes a constitutive component of low-affinity uptake.”  Huang N.C.et.al.   10449574
[2] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[3] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[4] “Regulation of NRT1 and NRT2 gene families of Arabidopsis thaliana: responses to nitrate provision.”  Okamoto M.et.al.   12668777
[5] “Nematode-induced changes of transporter gene expression in Arabidopsis roots.”  Hammes U.Z.et.al.   16478044
[6] “Nitrate transporters and peptide transporters.”  Tsay Y.F.et.al.   17481610
[7] “The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance.”  Li J.Y.et.al.   20501909

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MEVEEEVSRW EGYADWRNRA AVKGRHGGML AASFVLVVEI LENLAYLANA SNLVLYLREY 
61:	MHMSPSKSAN DVTNFMGTAF LLALLGGFLS DAFFSTFQIF LISASIEFLG LIILTIQART 
121:	PSLMPPSCDS PTCEEVSGSK AAMLFVGLYL VALGVGGIKG SLASHGAEQF DESTPKGRKQ 
181:	RSTFFNYFVF CLACGALVAV TFVVWLEDNK GWEWGFGVST IAIFVSILIF LSGSRFYRNK 
241:	IPCGSPLTTI LKVLLAASVK CCSSGSSSNA VASMSVSPSN HCVSKGKKEV ESQGELEKPR 
301:	QEEALPPRAQ LTNSLKVLNG AADEKPVHRL LECTVQQVED VKIVLKMLPI FACTIMLNCC 
361:	LAQLSTFSVQ QAASMNTKIG SLKIPPASLP IFPVVFIMIL APIYDHLIIP FARKATKTET 
421:	GVTHLQRIGV GLVLSILAMA VAALVEIKRK GVAKDSGLLD SKETLPVTFL WIALQYLFLG 
481:	SADLFTLAGL LEYFFTEAPS SMRSLATSLS WASLAMGYYL SSVIVSIVNS ITGSSGNTPW 
541:	LRGKSINRYK LDYFYWLMCV LSAANFLHYL FWAMRYKYRS TGSRS