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2.A.17.3.9
solute carrier family 15, member 3, SLC15A3, OCTP, PHT2, PHT3, of 581 aas and 12 TMSs in a 3 + 3 + 3 + 3 TMS arrangement. It is a histidine + di- and tri-peptide uptake transporter in immune cells (Verri et al. 2016). The functions, regulation and pathophysiology of PHT2 and PHT1, specifically in immunoregulation have been reviewed (Dong et al. 2023). 

Accession Number:Q8IY34
Protein Name:Solute carrier family 15 member 3
Length:581
Molecular Weight:63560.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Lysosome membrane1 / Multi-pass membrane protein2
Substrate tripeptide, dipeptide

Cross database links:

Entrez Gene ID: 51296   
Pfam: PF00854   
KEGG: hsa:51296    hsa:51296   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005765 C:lysosomal membrane
GO:0015293 F:symporter activity
GO:0006811 P:ion transport
GO:0006857 P:oligopeptide transport
GO:0015031 P:protein transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319
[4] “Human chromosome 11 DNA sequence and analysis including novel gene identification.”  Taylor T.D.et.al.   16554811
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Integral and associated lysosomal membrane proteins.”  Schroeder B.et.al.   17897319

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPAPRAREQP RVPGERQPLL PRGARGPRRW RRAAGAAVLL VEMLERAAFF GVTANLVLYL 
61:	NSTNFNWTGE QATRAALVFL GASYLLAPVG GWLADVYLGR YRAVALSLLL YLAASGLLPA 
121:	TAFPDGRSSF CGEMPASPLG PACPSAGCPR SSPSPYCAPV LYAGLLLLGL AASSVRSNLT 
181:	SFGADQVMDL GRDATRRFFN WFYWSINLGA VLSLLVVAFI QQNISFLLGY SIPVGCVGLA 
241:	FFIFLFATPV FITKPPMGSQ VSSMLKLALQ NCCPQLWQRH SARDRQCARV LADERSPQPG 
301:	ASPQEDIANF QVLVKILPVM VTLVPYWMVY FQMQSTYVLQ GLHLHIPNIF PANPANISVA 
361:	LRAQGSSYTI PEAWLLLANV VVVLILVPLK DRLIDPLLLR CKLLPSALQK MALGMFFGFT 
421:	SVIVAGVLEM ERLHYIHHNE TVSQQIGEVL YNAAPLSIWW QIPQYLLIGI SEIFASIPGL 
481:	EFAYSEAPRS MQGAIMGIFF CLSGVGSLLG SSLVALLSLP GGWLHCPKDF GNINNCRMDL 
541:	YFFLLAGIQA VTALLFVWIA GRYERASQGP ASHSRFSRDR G