2.A.17.4.11
Peptide transporter, Pep1, also called CptB, Opt-2 and Pep-2. It is of 835 aas and 11 TMSs. It transports di-, tri- and tetra-peptides including
phenylalanylmethionylarginylphenylalaninamide (FMRFamide) and
N-acetylaspartylglutamate, both neuropeptides found throughout the animal kingdom. In contrast to CptA (TC# 2.A.17.4.3), CptB has low-affinity for its substrates (Fei et al. 1998).
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| Accession Number: | Q21219 |
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| Protein Name: | Peptide transporter family 1 |
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| Length: | 835 |
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| Molecular Weight: | 94109.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Apical cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGYSESRSES VSSKGKTSYG HELETVPLPE KKIYTTWPDM IRHWPKTTLC IVSNEFCERF
61: SYYGMRTVLT FYLLNVLKFT DSQSTIFFNG FTVLCYTTPL LGSIVADGYI GKFWTIFSVS
121: ILYAIGQVVL ALASTKNFQS SVHPWMDLSG LLIIAFGTGG IKPCVSAFGG DQFELGQERM
181: LSLFFSMFYF SINAGSMIST FISPIFRSQP CLGQDSCYPM AFGIPAILMI VATLVFMGGS
241: FWYKKNPPKD NVFGEVSRLM FRAVGNKMKS GSTPKEHWLL HYLTTHDCAL DAKCLELQAE
301: KRNKNLCQKK KFIDDVRSLL RVLVMFLPVP MFWALYDQQG SVWLIQAIQM DCRLSDTLLL
361: LPDQMQTLNA VLILLFIPLF QVIIYPVAAK CVRLTPLRKM VTGGLLASLA FLITGFVQLQ
421: VNTTLPTLPE EGEASISFWN QFETDCTITV MSGIHKRVLP HDKYLHEDKK NKSGIYNLFT
481: TKSPAKGNGD WTLTYDLSYD GACGDTSKLE KTVKVTAKSK KIIYVGVGSF GYYQNTANTD
541: KPTDGTGEFS MGIVTVFNSS YGGNFAMCRQ NTSDFDVNHP CNPRHPADFY FWETDYNSHT
601: DDRDQNATIT GSLSSQPAVT YKQKSVKPGY WQLYYLLNTP KDVDRQTYNK TATLVAPTNY
661: GFHRVKQGGV FIYALTGTYE NPKIHELQIV QSNSVSILWQ IPQIVVITAA EILFSITGYE
721: FAYSQSAPSM KALVQALWLL TTAAGDSIIV VITILNLFEN MAVEFFVYAA AMFVVIAIFA
781: LLSIFYYTYN YYTTDEEDGE IGVDDEEEIE DHNPRYSIDN KGFHPDEKDT FDMHF