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2.A.18.2.1
General amino acid permease 1, AAP1 of 485 aas and 11 TMSs. It transports most neutral and acidic amino acids but not aspartate or the basic amino acids. It also transports the L-valine-phenazine-1-carboxylic acid conjugate (L-val-PCA) in Ricinus cotyledons (Xiao et al. 2023).

Accession Number:Q42400
Protein Name:AAP1 aka F19C14.3 aka ZCF54
Length:485
Molecular Weight:52895.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate amino acid, alpha-amino acid

Cross database links:

RefSeq: NP_176132.1   
Entrez Gene ID: 842205   
Pfam: PF01490   
KEGG: ath:AT1G58360   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015175 F:neutral amino acid transmembrane transporte...
GO:0015293 F:symporter activity
GO:0043090 P:amino acid import
GO:0015804 P:neutral amino acid transport
GO:0009624 P:response to nematode

References (13)

[1] “Cloning a plant amino acid transporter by functional complementation of a yeast amino acid transport mutant.”  Hsu L.-C.et.al.   8356039
[2] “Expression cloning in yeast of a cDNA encoding a broad specificity amino acid permease from Arabidopsis thaliana.”  Frommer W.B.et.al.   8327465
[3] “Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana genomic region located around the 100 map unit of chromosome 1.”  Kato A.et.al.   10548732
[4] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[5] “Differential expression of two related amino acid transporters with differing substrate specificity in Arabidopsis thaliana.”  Kwart M.et.al.   8281191
[6] “Substrate specificity and expression profile of amino acid transporters (AAPs) in Arabidopsis.”  Fischer W.-N.et.al.   7608199
[7] “Kinetics and specificity of a H+/amino acid transporter from Arabidopsis thaliana.”  Boorer K.J.et.al.   8567681
[8] “Topology of NAT2, a prototypical example of a new family of amino acid transporters.”  Chang H.-C.et.al.   9374550
[9] “Developmental control of H+/amino acid permease gene expression during seed development of Arabidopsis.”  Hirner B.et.al.   9675899
[10] “High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis.”  Okumoto S.et.al.   12244056
[11] “Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids.”  Fischer W.-N.et.al.   12148530
[12] “AAP1 transports uncharged amino acids into roots of Arabidopsis.”  Lee Y.-H.et.al.   17419840
[13] “AAP1 regulates import of amino acids into developing Arabidopsis embryos.”  Sanders A.et.al.   19392706

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MKSFNTEGHN HSTAESGDAY TVSDPTKNVD EDGREKRTGT WLTASAHIIT AVIGSGVLSL 
61:	AWAIAQLGWI AGTSILLIFS FITYFTSTML ADCYRAPDPV TGKRNYTYMD VVRSYLGGRK 
121:	VQLCGVAQYG NLIGVTVGYT ITASISLVAV GKSNCFHDKG HTADCTISNY PYMAVFGIIQ 
181:	VILSQIPNFH KLSFLSIMAA VMSFTYATIG IGLAIATVAG GKVGKTSMTG TAVGVDVTAA 
241:	QKIWRSFQAV GDIAFAYAYA TVLIEIQDTL RSSPAENKAM KRASLVGVST TTFFYILCGC 
301:	IGYAAFGNNA PGDFLTDFGF FEPFWLIDFA NACIAVHLIG AYQVFAQPIF QFVEKKCNRN 
361:	YPDNKFITSE YSVNVPFLGK FNISLFRLVW RTAYVVITTV VAMIFPFFNA ILGLIGAASF 
421:	WPLTVYFPVE MHIAQTKIKK YSARWIALKT MCYVCLIVSL LAAAGSIAGL ISSVKTYKPF 
481:	RTMHE