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2.A.18.2.1 General amino acid permease 1, AAP1 of 485 aas and 11 TMSs. It transports most neutral and acidic amino acids but not aspartate or the basic amino acids. It also transports the L-valine-phenazine-1-carboxylic acid conjugate (L-val-PCA) in Ricinus cotyledons (Xiao et al. 2023).
Accession Number:	Q42400
Protein Name:	AAP1 aka F19C14.3 aka ZCF54
Length:	485
Molecular Weight:	52895.00
Species:	Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	amino acid, alpha-amino acid

RefSeq:	NP_176132.1
Entrez Gene ID:	842205
Pfam:	PF01490
KEGG:	ath:AT1G58360
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015175 F:neutral amino acid transmembrane transporte... GO:0015293 F:symporter activity GO:0043090 P:amino acid import GO:0015804 P:neutral amino acid transport GO:0009624 P:response to nematode
References (13) [1] “Cloning a plant amino acid transporter by functional complementation of a yeast amino acid transport mutant.” Hsu L.-C.et.al. 8356039 [2] “Expression cloning in yeast of a cDNA encoding a broad specificity amino acid permease from Arabidopsis thaliana.” Frommer W.B.et.al. 8327465 [3] “Isolation and analysis of cDNA within a 300 kb Arabidopsis thaliana genomic region located around the 100 map unit of chromosome 1.” Kato A.et.al. 10548732 [4] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.” Theologis A.et.al. 11130712 [5] “Differential expression of two related amino acid transporters with differing substrate specificity in Arabidopsis thaliana.” Kwart M.et.al. 8281191 [6] “Substrate specificity and expression profile of amino acid transporters (AAPs) in Arabidopsis.” Fischer W.-N.et.al. 7608199 [7] “Kinetics and specificity of a H+/amino acid transporter from Arabidopsis thaliana.” Boorer K.J.et.al. 8567681 [8] “Topology of NAT2, a prototypical example of a new family of amino acid transporters.” Chang H.-C.et.al. 9374550 [9] “Developmental control of H+/amino acid permease gene expression during seed development of Arabidopsis.” Hirner B.et.al. 9675899 [10] “High affinity amino acid transporters specifically expressed in xylem parenchyma and developing seeds of Arabidopsis.” Okumoto S.et.al. 12244056 [11] “Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids.” Fischer W.-N.et.al. 12148530 [12] “AAP1 transports uncharged amino acids into roots of Arabidopsis.” Lee Y.-H.et.al. 17419840 [13] “AAP1 regulates import of amino acids into developing Arabidopsis embryos.” Sanders A.et.al. 19392706

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKSFNTEGHN HSTAESGDAY TVSDPTKNVD EDGREKRTGT WLTASAHIIT AVIGSGVLSL 
61:	AWAIAQLGWI AGTSILLIFS FITYFTSTML ADCYRAPDPV TGKRNYTYMD VVRSYLGGRK 
121:	VQLCGVAQYG NLIGVTVGYT ITASISLVAV GKSNCFHDKG HTADCTISNY PYMAVFGIIQ 
181:	VILSQIPNFH KLSFLSIMAA VMSFTYATIG IGLAIATVAG GKVGKTSMTG TAVGVDVTAA 
241:	QKIWRSFQAV GDIAFAYAYA TVLIEIQDTL RSSPAENKAM KRASLVGVST TTFFYILCGC 
301:	IGYAAFGNNA PGDFLTDFGF FEPFWLIDFA NACIAVHLIG AYQVFAQPIF QFVEKKCNRN 
361:	YPDNKFITSE YSVNVPFLGK FNISLFRLVW RTAYVVITTV VAMIFPFFNA ILGLIGAASF 
421:	WPLTVYFPVE MHIAQTKIKK YSARWIALKT MCYVCLIVSL LAAAGSIAGL ISSVKTYKPF 
481:	RTMHE

2.A.18.2.1
General amino acid permease 1, AAP1 of 485 aas and 11 TMSs. It transports most neutral and acidic amino acids but not aspartate or the basic amino acids. It also transports the L-valine-phenazine-1-carboxylic acid conjugate (L-val-PCA) in Ricinus cotyledons (Xiao et al. 2023).

Cross database links:

Gene Ontology

References (13)

External Searches:

Analyze:

2.A.18.2.1General amino acid permease 1, AAP1 of 485 aas and 11 TMSs. It transports most neutral and acidic amino acids but not aspartate or the basic amino acids. It also transports the L-valine-phenazine-1-carboxylic acid conjugate (L-val-PCA) in Ricinus cotyledons (Xiao et al. 2023).

Cross database links:

Gene Ontology

References (13)

External Searches:

Analyze:

2.A.18.2.1
General amino acid permease 1, AAP1 of 485 aas and 11 TMSs. It transports most neutral and acidic amino acids but not aspartate or the basic amino acids. It also transports the L-valine-phenazine-1-carboxylic acid conjugate (L-val-PCA) in Ricinus cotyledons (Xiao et al. 2023).