2.A.18.2.2
Lysine/histidine transporter, LHT1, of 446 aas and 10 or 11 TMSs (Chen and Bush 1997).  It has been reported to be an amino acid-proton symporter with a broad specificity for histidine, lysine, glutamic acid, alanine, serine, proline and glycine 90. It is involved in both apoplastic transport of amino acids in leaves and their uptake by roots (Hirner et al. 2006; Svennerstam et al. 2007; Svennerstam et al. 2008). There is some controversy about which amino acids it can take up, but it may play a role in fungicide uptake (Wu et al. 2021). There are six LHT genes in rice. The four members of cluster 1 show broad amino acid selectivity, while OsLHT5 and OsLHT6 may transport other substrates besides amino acids. The six OsLHT genes have different expression patterns at different developmental stages and in different tissues (Fan et al. 2023). Some OsLHT genes are responsive to PEG, NaCl and cold treatments.