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|---|---|
| Accession Number: | Q96QD8 |
| Protein Name: | Sodium-coupled neutral amino acid transporter 2 |
| Length: | 506 |
| Molecular Weight: | 56026.00 |
| Species: | [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | alpha-amino acid, L-methionine, L-asparagine, L-threonine, L-glutamine, L-proline, L-alanine, L-leucine, L-serine, glycine, L-phenylalanine |
Cross database links:
| RefSeq: | NP_061849.2 |
|---|---|
| Entrez Gene ID: | 54407 |
| Pfam: | PF01490 |
| OMIM: |
605180 gene |
| KEGG: | hsa:54407 hsa:54407 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015171
F:amino acid transmembrane transporter activity
GO:0015293
F:symporter activity
GO:0006865
P:amino acid transport
GO:0006814
P:sodium ion transport
GO:0014047
P:glutamate secretion
GO:0006811
P:ion transport
GO:0007269
P:neurotransmitter secretion
GO:0055085
P:transmembrane transport
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References (35)[1] “Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.” Hatanaka T.et.al. 10930503 [2] “Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.” Nagase T.et.al. 10718198 [3] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.” Nakajima D.et.al. 12168954 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.” Palii S.S.et.al. 14623874 [7] “SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress.” Bevilacqua E.et.al. 15922329 [8] “Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.” Zhang Y.et.al. 15951569 [9] “Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain.” Gonzalez-Gonzalez I.M.et.al. 15561425 [10] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [11] “Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.” Gaccioli F.et.al. 16621798 [12] “Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex.” Melone M.et.al. 16616430 [13] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.” Rikova K.et.al. 18083107 [14] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [15] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [16] “An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.” Heibeck T.H.et.al. 19534553 [17] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [18] “Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A.” Hatanaka T.et.al. 10930503 [19] “Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.” Nagase T.et.al. 10718198 [20] “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.” Nakajima D.et.al. 12168954 [21] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [22] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [23] “Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element.” Palii S.S.et.al. 14623874 [24] “SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress.” Bevilacqua E.et.al. 15922329 [25] “Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.” Zhang Y.et.al. 15951569 [26] “Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain.” Gonzalez-Gonzalez I.M.et.al. 15561425 [27] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [28] “Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation.” Gaccioli F.et.al. 16621798 [29] “Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex.” Melone M.et.al. 16616430 [30] “Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.” Rikova K.et.al. 18083107 [31] “Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks.” Wolf-Yadlin A.et.al. 17389395 [32] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [33] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [34] “An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells.” Heibeck T.H.et.al. 19534553 [35] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332
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1: MKKAEMGRFS ISPDEDSSSY SSNSDFNYSY PTKQAALKSH YADVDPENQN FLLESNLGKK 61: KYETEFHPGT TSFGMSVFNL SNAIVGSGIL GLSYAMANTG IALFIILLTF VSIFSLYSVH 121: LLLKTANEGG SLLYEQLGYK AFGLVGKLAA SGSITMQNIG AMSSYLFIVK YELPLVIQAL 181: TNIEDKTGLW YLNGNYLVLL VSLVVILPLS LFRNLGYLGY TSGLSLLCMV FFLIVVICKK 241: FQVPCPVEAA LIINETINTT LTQPTALVPA LSHNVTENDS CRPHYFIFNS QTVYAVPILI 301: FSFVCHPAVL PIYEELKDRS RRRMMNVSKI SFFAMFLMYL LAALFGYLTF YEHVESELLH 361: TYSSILGTDI LLLIVRLAVL MAVTLTVPVV IFPIRSSVTH LLCASKDFSW WRHSLITVSI 421: LAFTNLLVIF VPTIRDIFGF IGASAASMLI FILPSAFYIK LVKKEPMKSV QKIGALFFLL 481: SGVLVMTGSM ALIVLDWVHN APGGGH