2.A.18.7.4
Proline/alanine transporter of 488 aas and 10 TMSs, AAP24. The first 18 amino acids of the negatively charged N-terminal LdAAP24
tail are required for alanine transport and may facilitate the
electrostatic interactions of the entire negatively charged N-terminal
tail with the positively charged internal loops in the transmembrane
domain. This mechanism may underlie regulation of
substrate flux rate for this and other transporters (Schlisselberg et al. 2015).
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| Accession Number: | A4HUI4 |
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| Protein Name: | Putative amino acid transporter |
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| Length: | 488 |
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| Molecular Weight: | 53982.00 |
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| Species: | Leishmania infantum [5671] |
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| Number of TMSs: | 10 |
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| Substrate |
alanine, proline |
|---|
1: MSRLPSTASD NEPAHLTQME DERYRETLIE GFMSVPEVEG DEGASNGDPS CQQKDQKAQE
61: YVEMDDDDDM TVVRLAAGEL KENTNICKSA FHVFKANVGT GVFLLPTFYP DAGYVVSVIL
121: GVLIGAAVVD CTRLLVDVKI KINRSDVTTY SQVCRYVCGA GLGWFLFVAM CLAQFGFCLM
181: YTQLFGDTMV ELANFKGSKY LWVSVVFFLC FPMTCFSDNL SLLAITSIIA TVSVFYSLIC
241: CFAMSLMQLS QDGVHPSCDV AGNRIPVGWF NNLANNMMVL EGIAIILPVH AACTQKRLVP
301: KMATLVITGV IAWYILFGLT GYLAYGNSMT TSLVAKMAHS SWGTSVRVFF MLNLVFTYPV
361: QFMSAMQLID QTVRCKPRSW MGIGLRLLIN LVIWALAMGM PTSAVNTVVA FVGALPSVCM
421: VMIIPSILAM HVKYAVEHPD ADRNTLQYWK KIFVTAPCFT FKRIRCYVYL VVAVLIMVIG
481: TYSIAETL