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2.A.19.1.1 Ca²⁺:H⁺ antiporter (also catalyzes Na⁺:H⁺ and K⁺:H⁺ antiport in processes that have been shown to be physiologically important under certain conditions) (Ivey et al., 1993; Radchenko et al., 2006)
Accession Number:	P31801
Protein Name:	ChaA aka B1216
Length:	366
Molecular Weight:	39168.00
Species:	Escherichia coli [83333]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	calcium(2+), sodium(1+), potassium(1+), hydron

RefSeq:	AP_001844.1 NP_415734.1
Entrez Gene ID:	945790
Pfam:	PF01699
BioCyc:	EcoCyc:CHAA-MONOMER ECOL168927:B1216-MONOMER
KEGG:	ecj:JW1207 eco:b1216
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015386 F:potassium:hydrogen antiporter activity GO:0015385 F:sodium:hydrogen antiporter activity GO:0006816 P:calcium ion transport GO:0030007 P:cellular potassium ion homeostasis GO:0006883 P:cellular sodium ion homeostasis GO:0006813 P:potassium ion transport GO:0015992 P:proton transport GO:0051481 P:reduction of cytosolic calcium ion concentr... GO:0006814 P:sodium ion transport GO:0055085 P:transmembrane transport
References (5) [1] “Cloning and characterization of a putative Ca2+/H+ antiporter gene from Escherichia coli upon functional complementation of Na+/H+ antiporter-deficient strains by the overexpressed gene.” Ivey D.M.et.al. 8496184 [2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

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FASTA formatted sequence

1:	MSNAQEAVKT RHKETSLIFP VLALVVLFLW GSSQTLPVVI AINLLALIGI LSSAFSVVRH 
61:	ADVLAHRLGE PYGSLILSLS VVILEVSLIS ALMATGDAAP TLMRDTLYSI IMIVTGGLVG 
121:	FSLLLGGRKF ATQYMNLFGI KQYLIALFPL AIIVLVFPMA LPAANFSTGQ ALLVALISAA 
181:	MYGVFLLIQT KTHQSLFVYE HEDDSDDDDP HHGKPSAHSS LWHAIWLIIH LIAVIAVTKM 
241:	NASSLETLLD SMNAPVAFTG FLVALLILSP EGLGALKAVL NNQVQRAMNL FFGSVLATIS 
301:	LTVPVVTLIA FMTGNELQFA LGAPEMVVMV ASLVLCHISF STGRTNVLNG AAHLALFAAY 
361:	LMTIFA

2.A.19.1.1
Ca²⁺:H⁺ antiporter (also catalyzes Na⁺:H⁺ and K⁺:H⁺ antiport in processes that have been shown to be physiologically important under certain conditions) (Ivey et al., 1993; Radchenko et al., 2006)

Cross database links:

Gene Ontology

References (5)

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2.A.19.1.1Ca2+:H+ antiporter (also catalyzes Na+:H+ and K+:H+ antiport in processes that have been shown to be physiologically important under certain conditions) (Ivey et al., 1993; Radchenko et al., 2006)

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.19.1.1
Ca²⁺:H⁺ antiporter (also catalyzes Na⁺:H⁺ and K⁺:H⁺ antiport in processes that have been shown to be physiologically important under certain conditions) (Ivey et al., 1993; Radchenko et al., 2006)