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2.A.19.2.4
Low affinity Ca2+:H+/heavy metal cation (e.g., Mn2+, Mg2+, Cd2+, Ca2+):H+ antiporter, Cax2.  The apple (Malus domestiga) ortholog (CAX2L-2) functions positively in modulation of Ba2+ tolerance (Mei et al. 2023).

Accession Number:Q39254
Protein Name:Cax2
Length:441
Molecular Weight:48215.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:11
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate cadmium(2+), calcium(2+), magnesium(2+), hydron, manganese(2+)

Cross database links:

RefSeq: NP_566452.1   
Entrez Gene ID: 820532   
Pfam: PF01699   
KEGG: ath:AT3G13320   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0009705 C:plant-type vacuole membrane
GO:0015369 F:calcium:hydrogen antiporter activity
GO:0005515 F:protein binding
GO:0015691 P:cadmium ion transport
GO:0006816 P:calcium ion transport
GO:0006828 P:manganese ion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones.”  Sato S.et.al.   10819329
[2] “Empirical analysis of transcriptional activity in the Arabidopsis genome.”  Yamada K.et.al.   14593172
[3] “CAX1, an H+/Ca2+ antiporter from Arabidopsis.”  Hirschi K.D.et.al.   8710949
[4] “Structural determinants of Ca2+ transport in the Arabidopsis H+/Ca2+ antiporter CAX1.”  Shigaki T.et.al.   11562366
[5] “Manganese specificity determinants in the Arabidopsis metal/H+ antiporter CAX2.”  Shigaki T.et.al.   12496310
[6] “Evidence of differential pH regulation of the Arabidopsis vacuolar Ca2+/H+ antiporters CAX1 and CAX2.”  Pittman J.K.et.al.   15862304

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MSCCKVPVLI EAQVEMVSAN ELENKSLFRQ EEDATQTKEA SLMEQGSLST SFPQHTPKAP 
61:	KNSVLNSIKI VIFCNKLNLL LPFGPLAILV HYMIDSKGWV FLLTLVGITP LAERLGYATE 
121:	QLACYTGPTV GGLLNATFGN VTELIISIFA LKNGMIRVVQ LTLLGSILSN MLLVLGCAFF 
181:	CGGLVFYQKD QVFDKGIATV NSGLLLMAVM GILFPAVLHY THSEVHAGSS ELALSRFSSC 
241:	IMLIAYAAYL FFQLKSQSNS YSPLDEESNQ NEETSAEDED PEISKWEAII WLSILTAWVS 
301:	LLSGYLVDAI EGASVSWNIP IAFISTILLP IVGNAAEHAG AIMFAMKDKL DLSLGVAIGS 
361:	SIQISMFAVP FCVVIGWMMG QQMDLNFQLF ETAMLFITVI VVAFFLQEGS SNYFKGLMLI 
421:	LCYLIVAASF FVHEDPHQDG I