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2.A.19.2.5 High affinity vacuolar (tonoplast) Ca²⁺:H⁺ antiporter (also exports Cd²⁺ and Zn²⁺; Shigaki et al., 2005) highly expressed in roots (Cheng et al., 2005) (exhibits phenotypes characteristic of CAX1, but also determines sensitivities to salt, lithium and low pH (Zhao et al., 2008)
Accession Number:	Q93Z81
Protein Name:	Cax3
Length:	459
Molecular Weight:	49851.00
Species:	Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Vacuole membrane¹ / Multi-pass membrane protein²
Substrate	cadmium(2+), calcium(2+), zinc(2+), hydron

RefSeq:	NP_190754.2
Entrez Gene ID:	824349
Pfam:	PF01699
KEGG:	ath:AT3G51860
Gene Ontology GO:0016021 C:integral to membrane GO:0009705 C:plant-type vacuole membrane GO:0015369 F:calcium:hydrogen antiporter activity GO:0005515 F:protein binding GO:0006816 P:calcium ion transport GO:0006874 P:cellular calcium ion homeostasis GO:0030026 P:cellular manganese ion homeostasis GO:0006882 P:cellular zinc ion homeostasis GO:0010351 P:lithium ion transport GO:0006793 P:phosphorus metabolic process GO:0051592 P:response to calcium ion GO:0009624 P:response to nematode GO:0006814 P:sodium ion transport GO:0055085 P:transmembrane transport
References (6) [1] “Characterization of CAX-like genes in plants: implications for functional diversity.” Shigaki T.et.al. 11080595 [2] “Fine sequence analysis of 60 kb around the Arabidopsis thaliana AtEm1 locus on chromosome III.” Comella P.et.al. 10645728 [3] “Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.” Salanoubat M.et.al. 11130713 [4] “Empirical analysis of transcriptional activity in the Arabidopsis genome.” Yamada K.et.al. 14593172 [5] “Structural determinants of Ca2+ transport in the Arabidopsis H+/Ca2+ antiporter CAX1.” Shigaki T.et.al. 11562366 [6] “Functional association of Arabidopsis CAX1 and CAX3 is required for normal growth and ion homeostasis.” Cheng N.-H.et.al. 16055687

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MGSIVEPWAA IAENGNANVT AKGSSRELRH GRTAHNMSSS SLRKKSDLRL VQKVPCKTLK 
61:	NILSNLQEVI LGTKLTLLFL AIPLAILANS YNYGRPLIFG LSLIGLTPLA ERVSFLTEQL 
121:	AFYTGPTVGG LLNATCGNAT ELIIAILALA NNKVAVVKYS LLGSILSNLL LVLGTSLFFG 
181:	GIANIRREQR FDRKQADVNF FLLLMGLLCH LLPLLLKYAA TGEVSTSMIN KMSLTLSRTS 
241:	SIVMLIAYIA YLIFQLWTHR QLFEAQQDDD DAYDDEVSVE ETPVIGFWSG FAWLVGMTIV 
301:	IALLSEYVVD TIEDASDSWG LSVSFISIIL LPIVGNAAEH AGAIIFAFKN KLDISLGVAL 
361:	GSATQISLFV VPLSVIVAWI LGIKMDLNFN ILETSSLALA IIITAFTLQD GTSHYMKGLV 
421:	LLLCYVIIAA CFFVDQIPQP NDLDVGLQPM NNLGEVFSA

2.A.19.2.5
High affinity vacuolar (tonoplast) Ca²⁺:H⁺ antiporter (also exports Cd²⁺ and Zn²⁺; Shigaki et al., 2005) highly expressed in roots (Cheng et al., 2005) (exhibits phenotypes characteristic of CAX1, but also determines sensitivities to salt, lithium and low pH (Zhao et al., 2008)

Cross database links:

Gene Ontology

References (6)

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2.A.19.2.5High affinity vacuolar (tonoplast) Ca2+:H+ antiporter (also exports Cd2+ and Zn2+; Shigaki et al., 2005) highly expressed in roots (Cheng et al., 2005) (exhibits phenotypes characteristic of CAX1, but also determines sensitivities to salt, lithium and low pH (Zhao et al., 2008)

Cross database links:

Gene Ontology

References (6)

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