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2.A.19.2.9
Vacuolar cation:proton exchanger, Cax4 (transports Cd2+>Zn2+>Ca2+>Mn2+) (Cheng et al., 2002; Mei et al., 2009).  The rice orthologue, Cax4, may transport Ca2+, Mn2+ and Cu2+, and functions in salt stress (Yamada et al. 2014). The A. thaliana protein contributes to Cd2+ resistance (Liao et al. 2019).

Accession Number:Q945S5
Protein Name:Vacuolar cation/proton exchanger 4
Length:446
Molecular Weight:48699.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Vacuole membrane1 / Multi-pass membrane protein2
Substrate cadmium(2+), calcium(2+), copper(2+), zinc(2+), hydron, manganese(2+)

Cross database links:

Pfam: PF01699   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0009705 C:plant-type vacuole membrane
GO:0015369 F:calcium:hydrogen antiporter activity
GO:0009733 P:response to auxin stimulus
GO:0048364 P:root development

References (4)

[1] “Characterization of CAX4, an Arabidopsis H(+)/cation antiporter.”  Cheng N.-H.et.al.   11950973
[2] “Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.”  Tabata S.et.al.   11130714
[3] “Increased calcium levels and prolonged shelf life in tomatoes expressing Arabidopsis H+/Ca2+ transporters.”  Park S.et.al.   16244156
[4] “Enhanced Cd(2+)-selective root-tonoplast-transport in tobaccos expressing Arabidopsis cation exchangers.”  Koren'kov V.et.al.   16845524

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSSISTESSS NLSLLENGGG GSDKPTAETS RRVRRTVSAS SLIRKRSDLK LISRVRWEFM 
61:	RRILTNLQEV LLGTKLFILF PAVPLAVVAH RYDCPRAWVF ALSLLGLTPL AERISFLTEQ 
121:	IAFHTGPTVG GLMNATCGNA TEMIIAILAV GQRKMRIVKL SLLGSILSNL LFVLGTSLFL 
181:	GGISNLRKHQ SFDPRQGDMN SMLLYLALLC QTLPMIMRFT MEAEEYDGSD VVVLSRASSF 
241:	VMLIAYLAFL IFHLFSSHLS PPPPPLPQRE DVHDDDVSDK EEEGAVIGMW SAIFWLIIMT 
301:	LLVALLSDYL VSTIQDAADS WGLSVGFIGI ILLPIVGNAA EHAGAVIFAF RNKLDITLGI 
361:	ALGSATQIAL FVVPVTVLVA WTMGIEMDLN FNLLETACFA LSILVTSLVL QDGTSNYMKG 
421:	LVLLLCYVVI AACFFVSNSP SSKLLF