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|---|---|
| Accession Number: | Q9UPR5 |
| Protein Name: | Sodium/calcium exchanger 2 |
| Length: | 921 |
| Molecular Weight: | 100368.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 11 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+), sodium(1+) |
Cross database links:
| Entrez Gene ID: | 6543 |
|---|---|
| Pfam: | PF03160 PF01699 |
| KEGG: | hsa:6543 |
Gene Ontology
GO:0043197
C:dendritic spine
GO:0016021
C:integral to membrane
GO:0005874
C:microtubule
GO:0005739
C:mitochondrion
GO:0043025
C:neuronal cell body
GO:0005886
C:plasma membrane
GO:0005432
F:calcium:sodium antiporter activity
GO:0007596
P:blood coagulation
GO:0060402
P:calcium ion transport into cytosol
GO:0007154
P:cell communication
GO:0006811
P:ion transport
GO:0033280
P:response to vitamin D
GO:0021537
P:telencephalon development
GO:0055085
P:transmembrane transport
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References (2)[1] “Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.” Kikuno R.et.al. 10470851 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MAPLALVGVT LLLAAPPCSG AATPTPSLPP PPANDSDTST GGCQGSYRCQ PGVLLPVWEP 61: DDPSLGDKAA RAVVYFVAMV YMFLGVSIIA DRFMAAIEVI TSKEKEITIT KANGETSVGT 121: VRIWNETVSN LTLMALGSSA PEILLSVIEV CGHNFQAGEL GPGTIVGSAA FNMFVVIAVC 181: IYVIPAGESR KIKHLRVFFV TASWSIFAYV WLYLILAVFS PGVVQVWEAL LTLVFFPVCV 241: VFAWMADKRL LFYKYVYKRY RTDPRSGIII GAEGDPPKSI ELDGTFVGAE APGELGGLGP 301: GPAEARELDA SRREVIQILK DLKQKHPDKD LEQLVGIANY YALLHQQKSR AFYRIQATRL 361: MTGAGNVLRR HAADASRRAA PAEGAGEDED DGASRIFFEP SLYHCLENCG SVLLSVTCQG 421: GEGNSTFYVD YRTEDGSAKA GSDYEYSEGT LVFKPGETQK ELRIGIIDDD IFEEDEHFFV 481: RLLNLRVGDA QGMFEPDGGG RPKGRLVAPL LATVTILDDD HAGIFSFQDR LLHVSECMGT 541: VDVRVVRSSG ARGTVRLPYR TVDGTARGGG VHYEDACGEL EFGDDETMKT LQVKIVDDEE 601: YEKKDNFFIE LGQPQWLKRG ISALLLNQGD GDRKLTAEEE EARRIAEMGK PVLGENCRLE 661: VIIEESYDFK NTVDKLIKKT NLALVIGTHS WREQFLEAIT VSAGDEEEEE DGSREERLPS 721: CFDYVMHFLT VFWKVLFACV PPTEYCHGWA CFGVSILVIG LLTALIGDLA SHFGCTVGLK 781: DSVNAVVFVA LGTSIPDTFA SKVAALQDQC ADASIGNVTG SNAVNVFLGL GVAWSVAAVY 841: WAVQGRPFEV RTGTLAFSVT LFTVFAFVGI AVLLYRRRPH IGGELGGPRG PKLATTALFL 901: GLWLLYILFA SLEAYCHIRG F