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2.A.19.4.4
K+-dependent Na+/Ca2+ antiporter, NCKX6 (Cai and Lytton, 2004). CCKX6 (NCLX) is an essential component of the mitochondrial Na+/Ca2+ exchanger (Palty et al., 2010; Drago et al., 2011).  It usually mediates mitochondrial Ca2+ extrusion (De Marchi et al. 2014). However, the mitochondrial calcium uniporter channel (MCU) and mitochondrial Na+ /Ca2+ exchanger, NCLX, mediate Ca2+ entry into and release from this organelle and couple cytosolic Ca2+ and Na+ fluctuations with cellular energetics (Verkhratsky et al. 2017). Abnormal levels occur in plasma neuron-derived extracellular vesicles of early schizophrenia and other neurodevelopmental diseases (Goetzl et al. 2022). Members of this family have the Glt fold (Ferrada and Superti-Furga 2022).  The mitochondrial calcium uniporter (MCU) is involved in an ischemic postconditioning effect against ischemic reperfusion brain injury in mice (Sasaki et al. 2024). Mitochondrial sodium/calcium exchanger (NCLX) regulates basal and starvation-induced autophagy through calcium signaling (Ramos et al. 2024).

Accession Number:Q6J4K2
Protein Name:Sodium/potassium/calcium exchanger 6
Length:584
Molecular Weight:64231.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate calcium(2+), sodium(1+), potassium(1+)

Cross database links:

RefSeq: NP_079235.2   
Entrez Gene ID: 80024   
Pfam: PF01699   
OMIM: 609841  gene
KEGG: hsa:80024    hsa:80024   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015297 F:antiporter activity
GO:0006816 P:calcium ion transport
GO:0050896 P:response to stimulus
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport
GO:0006811 P:ion transport

References (8)

[1] “Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger.”  Palty R.et.al.   15060069
[2] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger.”  Palty R.et.al.   15060069
[6] “The finished DNA sequence of human chromosome 12.”  Scherer S.E.et.al.   16541075
[7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAGRRLNLRW ALSVLCVLLM AETVSGTRGS STGAHISPQF PASGVNQTPV VDCRKVCGLN 
61:	VSDRCDFIRT NPDCHSDGGY LDYLEGIFCH FPPSLLPLAV TLYVSWLLYL FLILGVTAAK 
121:	FFCPNLSAIS TTLKLSHNVA GVTFLAFGNG APDIFSALVA FSDPHTAGLA LGALFGAGVL 
181:	VTTVVAGGIT ILHPFMAASR PFFRDIVFYM VAVFLTFLML FRGRVTLAWA LGYLGLYVFY 
241:	VVTVILCTWI YQRQRRGSLF CPMPVTPEIL SDSEEDRVSS NTNSYDYGDE YRPLFFYQET 
301:	TAQILVRALN PLDYMKWRRK SAYWKALKVF KLPVEFLLLL TVPVVDPDKD DQNWKRPLNC 
361:	LHLVISPLVV VLTLQSGTYG VYEIGGLVPV WVVVVIAGTA LASVTFFATS DSQPPRLHWL 
421:	FAFLGFLTSA LWINAAATEV VNILRSLGVV FRLSNTVLGL TLLAWGNSIG DAFSDFTLAR 
481:	QGYPRMAFSA CFGGIIFNIL VGVGLGCLLQ ISRSHTEVKL EPDGLLVWVL AGALGLSLVF 
541:	SLVSVPLQCF QLSRVYGFCL LLFYLNFLVV ALLTEFGVIH LKSM