| |
|---|---|
| Accession Number: | O60721 |
| Protein Name: | Sodium/potassium/calcium exchanger 1 |
| Length: | 1099 |
| Molecular Weight: | 121374.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 9 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | calcium(2+), sodium(1+), potassium(1+) |
Cross database links:
| Entrez Gene ID: | 9187 |
|---|---|
| Pfam: | PF01699 |
| KEGG: | hsa:9187 hsa:9187 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0019867
C:outer membrane
GO:0008273
F:calcium, potassium:sodium antiporter activity
GO:0005515
F:protein binding
GO:0015293
F:symporter activity
GO:0009642
P:response to light intensity
GO:0007601
P:visual perception
| |
References (10)[1] “Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger.” Tucker J.E.et.al. 9856482 [2] “cDNA cloning of the human retinal rod Na-Ca + K exchanger: comparison with a revised bovine sequence.” Tucker J.E.et.al. 9478004 [3] “Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.” Ishikawa K.et.al. 9734811 [4] “The retinal rod Na(+)/Ca(2+),K(+) exchanger contains a noncleaved signal sequence required for translocation of the N-terminus.” McKiernan C.J.et.al. 10608890 [5] “A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness.” Riazuddin S.A.et.al. 20850105 [6] “Chromosomal localization and genomic organization of the human retinal rod Na-Ca+K exchanger.” Tucker J.E.et.al. 9856482 [7] “cDNA cloning of the human retinal rod Na-Ca + K exchanger: comparison with a revised bovine sequence.” Tucker J.E.et.al. 9478004 [8] “Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.” Ishikawa K.et.al. 9734811 | |
External Searches:
|
Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
|
|||
1: MGKLIRMGPQ ERWLLRTKRL HWSRLLFLLG MLIIGSTYQH LRRPRGLSSL WAAVSSHQPI 61: KLASRDLSSE EMMMMSSSPS KPSSEMGGKM LVPQASVGSD EATLSMTVEN IPSMPKRTAK 121: MIPTTTKNNY SPTAAGTERR KEDTPTSSRT LTYYTSTSSR QIVKKYTPTP RGEMKSYSPT 181: QVREKVKYTP SPRGRRVGTY VPSTFMTMET SHAITPRTTV KDSDITATYK ILETNSLKRI 241: MEETTPTTLK GMFDSTPTFL THEVEANVLT SPRSVMEKNN LFPPRRVESN SSAHPWGLVG 301: KSNPKTPQGT VLLHTPATSE GQVTISTMTG SSPAETKAFT AAWSLRNPSP RTSVSAIKTA 361: PAIVWRLAKK PSTAPSTSTT PTVRAKLTMQ VHHCVVVKPT PAMLTTPSPS LTTALLPEEL 421: SPSPSVLPPS LPDLHPKGEY PPDLFSVEER RQGWVVLHVF GMMYVFVALA IVCDEYFVPA 481: LGVITDKLQI SEDVAGATFM AAGGSAPELF TSLIGVFISH SNVGIGTIVG SAVFNILFVI 541: GTCSLFSREI LNLTWWPLFR DVSFYILDLI MLILFFLDSL IAWWESLLLL LAYAFYVFTM 601: KWNKHIEVWV KEQLSRRPVA KVMALEDLSK PGDGAIAVDE LQDNKKLKLP SLLTRGSSST 661: SLHNSTIRST IYQLMLHSLD PLREVRLAKE KEEESLNQGA RAQPQAKAES KPEEEEPAKL 721: PAVTVTPAPV PDIKGDQKEN PGGQEDVAEA ESTGEMPGEE GETAGEGETE EKSGGETQPE 781: GEGETETQGK GEECEDENEA EGKGDNEGED EGEIHAEDGE MKGNEGETES QELSAENHGE 841: AKNDEKGVED GGGSDGGDSE EEEEEEEEQE EEEEEEEQEE EEEEEEEEEE KGNEEPLSLD 901: WPETRQKQAI YLFLLPIVFP LWLTVPDVRR QESRKFFVFT FLGSIMWIAM FSYLMVWWAH 961: QVGETIGISE EIMGLTILAA GTSIPDLITS VIVARKGLGD MAVSSSVGSN IFDITVGLPV 1021: PWLLFSLING LQPVPVSSNG LFCAIVLLFL MLLFVISSIA SCKWRMNKIL GFTMFLLYFV 1081: FLIISVMLED RIISCPVSV