2.A.19.8.1 Calcium:proton exchanger, CAX(CK31). The function was demonstrated by purification and reconstitution in liposomes (Ridilla et al. 2012). The protein forms dimers in the membrane but can be purified as a monomer. The dimer interface seems to involve TMSs 2 and 6 (Ridilla et al. 2012).
|
Accession Number: | B0SUU5 |
Protein Name: | Sodium/calcium exchanger membrane region |
Length: | 440 |
Molecular Weight: | 46849.00 |
Species: | Caulobacter sp. (strain K31) [366602] |
Number of TMSs: | 14 |
Substrate |
calcium(2+), hydron |
---|
1: MSLSSSQARQ LWIPVGLAVA VMLPALALRI AGWRPNPVLD IGVFGAAILA AGFLLSWGAE
61: AAEKYLSQGL ILAAVALVTV LPEYAVDIYY AFQAGRSPSE GYVAFAAANM TGANRLLIGL
121: AWPAMVLLHW WKNRQRGIEL APVNAIEIVV LALSSAYAFV IILKNTISAW DAVVLVGLFG
181: LYLWRVSKLP KAQDEDEGEE PGPGAVIAKL SNTTRWTVMI AMTVVAAGVI LVVAEPFAES
241: MIDGGRALGI DQFLLIQWLA PIASEAPAVV IAVLFVLAGR AAAGLVAMIS DKINQWTLLV
301: GMLPLAMSLG AGQLRALPLD ARQHEEFFLT AAQSLFGLAL LLRLRLSVIG AIALLGLFVA
361: QLMIALSLRQ DEARDIAALT AVAWGYLVLA GLLFALNWRA IAGLLSTAFS LTANLETVAD
421: PHLARPTPSP ERARDDAQEH