2.A.19.8.2
Ca2+:H+ antiporter of 405 aas, CAX_Af. The inward facing 3-d structure has been solved to 2.3 Å resolution (Nishizawa et al. 2013). The authors compare this structure to the outward facing 1.9 Å structure of NCX_Mj (TC# 2.A.19.5.3) and suggest that Ca2+ or H+ binds to the cation-binding site mutually exclusively. The first and sixth TMSs alternately create hydrophilic cavities on the intra- and extracellluar sides of the membrane. The inward and outward-facing transitions are triggered by ion binding (Nishizawa et al. 2013).
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| Accession Number: | O29988 |
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| Protein Name: | Putative uncharacterized protein |
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| Length: | 394 |
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| Molecular Weight: | 43713.00 |
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| Species: | Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) [224325] |
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| Number of TMSs: | 12 |
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| Substrate |
calcium(2+), hydron |
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1: MDFTKEKFQL LAISSLTLPW LISLAFNYHH PALTQTLLSG LAVVSASFLI SWAAETAEMD
61: VPRSFSLAIV ALLAVLPEYA VDGYFAWKAG SVGGEYVHYA TANMTGANRL LIGIGWSLVA
121: FIAFRTLKSK EVELDDGIRL EIFFLFLATL YAFTLPLKGH ISPFDALVFV SLYAIYIYLS
181: TKAEREEVEV GGVPAYLCSL KTETRRLSVV VLFLFAGFTI LMSVEAFSEG LLETARIAGI
241: DEFLAVQWIA PLASESPELI VAIYFVRRFR VSASMNALIS SKVNQWTLLI GTIAIIYSIS
301: AFKLQSLPLD ARQSEEVLLT AAQSLFAVAI LLDLKISWKE ASALFLLFIV QLLFPGVEVR
361: YIISAIYIIL SLPILFAKRK EIVESFRTVK RLIS