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2.A.2.4.7
Solute carrier family 45, member 4, SLC45A4.  Transports sucrose by a proton symport mechanism.  Found ubiquitously throughout the tissues of the body (Bartölke et al. 2014). SLC45A4 encodes a mitochondrial putrescine transporter that promotes γ-aminobutyric acid (GABA) de novo synthesis (Colson et al. 2024). The expression of SLC45A4 also has a strong positive correlation with the cellular level of GABA.

Accession Number:Q5BKX6
Protein Name:Solute carrier family 45 member 4
Length:768
Molecular Weight:83878.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate putrescine, sucrose

Cross database links:

Entrez Gene ID: 57210   
KEGG: hsa:57210    hsa:57210   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0006810 P:transport

References (10)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “DNA sequence and analysis of human chromosome 8.”  Nusbaum C.et.al.   16421571
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.”  Hirosawa M.et.al.   10574461
[5] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “DNA sequence and analysis of human chromosome 8.”  Nusbaum C.et.al.   16421571
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[9] “Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.”  Hirosawa M.et.al.   10574461
[10] “A quantitative atlas of mitotic phosphorylation.”  Dephoure N.et.al.   18669648

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKMAPQNADP ESMQVQELSV PLPDPQKAGG AEAENCETIS EGSIDRIPMR LWVMHGAVMF 
61:	GREFCYAMET ALVTPILLQI GLPEQYYSLT WFLSPILGLI FTPLIGSASD RCTLSWGRRR 
121:	PFILALCVGV LFGVALFLNG SAIGLALGDV PNRQPIGIVL TVLGVVVLDF SADATEGPIR 
181:	AYLLDVVDSE EQDMALNIHA FSAGLGGAIG YVLGGLDWTQ TFLGSWFRTQ NQVLFFFAAI 
241:	IFTVSVALHL FSIDEEQYSP QQERSAEEPG ALDGGEPHGV PAFPDEVQSE HELALDYPDV 
301:	DIMRSKSDSA LHVPDTALDL EPELLFLHDI EPSIFHDASY PATPRSTSQE LAKTKLPRLA 
361:	TFLKEAAKED ETLLDNHLNE AKVPNGSGSP TKDALGGYTR VDTKPSATSS SMRRRRHAFR 
421:	RQASSTFSYY GKLGSHCYRY RRANAVVLIK PSRSMSDLYD MQKRQRQHRH RNQSGATTSS 
481:	GDTESEEGEG ETTVRLLWLS MLKMPRELMR LCLCHLLTWF SVIAEAVFYT DFMGQVIFEG 
541:	DPKAPSNSTA WQAYNAGVKM GCWGLVIYAA TGAICSALLQ KYLDNYDLSV RVIYVLGTLG 
601:	FSVGTAVMAM FPNVYVAMVT ISTMGIVSMS ISYCPYALLG QYHDIKQYIH HSPGNSKRGF 
661:	GIDCAILSCQ VYISQILVAS ALGGVVDAVG TVRVIPMVAS VGSFLGFLTA TFLVIYPNVS 
721:	EEAKEEQKGL SSPLAGEGRA GGNSEKPTVL KLTRKEGLQG PVETESVV