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|---|---|
| Accession Number: | Q8N695 |
| Protein Name: | Sodium-coupled monocarboxylate transporter 1 |
| Length: | 610 |
| Molecular Weight: | 66578.00 |
| Species: | [9606] |
| Number of TMSs: | 13 |
| Location1 / Topology2 / Orientation3: | Apical cell membrane1 / Multi-pass membrane protein2 |
| Substrate | sodium(1+), acetate, lactate, pyruvate, propionate, butyrate |
Cross database links:
| RefSeq: | NP_666018.3 |
|---|---|
| Entrez Gene ID: | 160728 |
| Pfam: | PF00474 |
| OMIM: |
608044 gene |
| KEGG: | hsa:160728 hsa:160728 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0016021
C:integral to membrane
GO:0022803
F:passive transmembrane transporter activity
GO:0015293
F:symporter activity
GO:0006915
P:apoptosis
GO:0006814
P:sodium ion transport
GO:0055085
P:transmembrane transport
GO:0005886
C:plasma membrane
GO:0006915
P:apoptotic process
GO:0006811
P:ion transport
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References (28)[1] “Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.” Rodriguez A.-M.et.al. 12107270 [2] “SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers.” Li H.et.al. 12829793 [3] “Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids.” Miyauchi S.et.al. 14966140 [4] “The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter.” Coady M.J.et.al. 15090606 [5] “The finished DNA sequence of human chromosome 12.” Scherer S.E.et.al. 16541075 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters.” Lacroix L.et.al. 15001644 [8] “Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer.” Ueno M.et.al. 15361710 [9] “Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.” Hong C.et.al. 15867356 [10] “SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.” Thangaraju M.et.al. 17178845 [11] “Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain.” Martin P.M.et.al. 16805814 [12] “Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8).” Itagaki S.et.al. 16729224 [13] “Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor.” Park J.Y.et.al. 18037591 [14] “Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract.” Gopal E.et.al. 17245649 [15] “Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes.” Rodriguez A.-M.et.al. 12107270 [16] “SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers.” Li H.et.al. 12829793 [17] “Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids.” Miyauchi S.et.al. 14966140 [18] “The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter.” Coady M.J.et.al. 15090606 [19] “The finished DNA sequence of human chromosome 12.” Scherer S.E.et.al. 16541075 [20] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [21] “Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters.” Lacroix L.et.al. 15001644 [22] “Aberrant methylation and histone deacetylation associated with silencing of SLC5A8 in gastric cancer.” Ueno M.et.al. 15361710 [23] “Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.” Hong C.et.al. 15867356 [24] “SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.” Thangaraju M.et.al. 17178845 [25] “Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain.” Martin P.M.et.al. 16805814 [26] “Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8).” Itagaki S.et.al. 16729224 [27] “Candidate tumor suppressor gene SLC5A8 is frequently down-regulated by promoter hypermethylation in prostate tumor.” Park J.Y.et.al. 18037591 [28] “Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract.” Gopal E.et.al. 17245649
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MDTPRGIGTF VVWDYVVFAG MLVISAAIGI YYAFAGGGQQ TSKDFLMGGR RMTAVPVALS 61: LTASFMSAVT VLGTPSEVYR FGAIFSIFAF TYFFVVVISA EVFLPVFYKL GITSTYEYLE 121: LRFNKCVRLC GTVLFIVQTI LYTGIVIYAP ALALNQVTGF DLWGAVVATG VVCTFYCTLG 181: GLKAVIWTDV FQVGIMVAGF ASVIIQAVVM QGGISTILND AYDGGRLNFW NFNPNPLQRH 241: TFWTIIIGGT FTWTSIYGVN QSQVQRYISC KSRFQAKLSL YINLVGLWAI LTCSVFCGLA 301: LYSRYHDCDP WTAKKVSAPD QLMPYLVLDI LQDYPGLPGL FVACAYSGTL STVSSSINAL 361: AAVTVEDLIK PYFRSLSERS LSWISQGMSV VYGALCIGMA ALASLMGALL QAALSVFGMV 421: GGPLMGLFAL GILVPFANSI GALVGLMAGF AISLWVGIGA QIYPPLPERT LPLHLDIQGC 481: NSTYNETNLM TTTEMPFTTS VFQIYNVQRT PLMDNWYSLS YLYFSTVGTL VTLLVGILVS 541: LSTGGRKQNL DPRYILTKED FLSNFDIFKK KKHVLSYKSH PVEDGGTDNP AFNHIELNSD 601: QSGKSNGTRL