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2.A.21.5.7
Sodium-dependent multivitamin transporter (Na+-dependent multivitamin transporter) (Solute carrier family 5 member 6) of 521 aas and 11 TMSs.  It transports biotin (vitamin B7), pantothenate (vitamin B5), α-lipoic acid, and iodide (Holling et al. 2022). Compound heterozygous SLC5A6 variants have been reported in individuals with variable multisystemic disorder, including failure to thrive, developmental delay, seizures, cerebral palsy, brain atrophy, gastrointestinal problems, immunodeficiency, and/or osteopenia. Holling et al. 2022 expanded the phenotypic spectrum associated with biallelic SLC5A6 variants affecting function by reporting five individuals from three families with motor neuropathies. Missense variants p.(Tyr162Cys) and p.(Ser429Gly) did not affect plasma membrane localization of the ectopically expressed multivitamin transporter, suggesting reduced function, such as lower catalytic activity (Holling et al. 2022).

Accession Number:Q9Y289
Protein Name:Sodium-dependent multivitamin transporter
Length:635
Molecular Weight:68642.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate iodide, sodium(1+), pantothenate, biotin, vitamin

Cross database links:

Entrez Gene ID: 8884   
Pfam: PF00474   
KEGG: hsa:8884   

Gene Ontology

GO:0031526 C:brush border membrane
GO:0005887 C:integral to plasma membrane
GO:0005624 C:membrane fraction
GO:0012506 C:vesicle membrane
GO:0008523 F:sodium-dependent multivitamin transmembrane transporter activity
GO:0006768 P:biotin metabolic process
GO:0015878 P:biotin transport
GO:0015939 P:pantothenate metabolic process
GO:0015887 P:pantothenate transmembrane transport

References (5)

[1] “Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.”  Wang H.et.al.   10329687
[2] “Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter.”  Prasad P.D.et.al.   10334869
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.”  Hillier L.W.et.al.   15815621
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG WGRHTVGELL 
61:	MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW FLGCCYFLGL LIPAHIFIPV 
121:	FYRLHLTSAY EYLELRFNKT VRVCGTVTFI FQMVIYMGVV LYAPSLALNA VTGFDLWLSV 
181:	LALGIVCTVY TALGGLKAVI WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR 
241:	ISGFELDPDP FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF 
301:	QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG LPGLFIACLF 
361:	SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR GLAFGYGLLC LGMAYISSQM 
421:	GPVLQAAISI FGMVGGPLLG LFCLGMFFPC ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG 
481:	SSMPPSPSNG SSFSLPTNLT VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV 
541:	VGLIVSLLTG RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP 
601:	RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL