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2.A.21.7.2
Acetate/glyoxylate/pyruvate permease, ActP or YjcG (Gimenez et al., 2003).  Also transports tellurite (TeO32-) (Elías et al. 2015). It may depend on the 2 TMS auxiliary subunit, YjcH (TC#9.B.136.1.1), the gene for which is adjacent to the yjcG gene (Zhuge et al. 2019). Expression of these two genes is coordinately regulated and plays a role in the bacterial growth in macrophage. Intracellular acetate consumption during facultative intracellular bacterial replication within macrophages promotes immunomodulatory disorders, resulting in excessively pro-inflammatory responses of host macrophages (Zhuge et al. 2019).

Accession Number:P32705
Protein Name:YjcG
Length:549
Molecular Weight:59197.00
Species:Escherichia coli [83333]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate acetate, glyoxylic acid

Cross database links:

DIP: DIP-12552N
RefSeq: AP_004568.1    NP_418491.1   
Entrez Gene ID: 948575   
Pfam: PF00474   
BioCyc: EcoCyc:YJCG-MONOMER    ECOL168927:B4067-MONOMER   
KEGG: ecj:JW4028    eco:b4067   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0015123 F:acetate transmembrane transporter activity
GO:0015293 F:symporter activity
GO:0006814 P:sodium ion transport
GO:0055085 P:transmembrane transport

References (6)

[1] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.”  Blattner F.R.et.al.   8265357
[2] “The complete genome sequence of Escherichia coli K-12.”  Blattner F.R.et.al.   9278503
[3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.”  Hayashi K.et.al.   16738553
[4] “The gene yjcG, cotranscribed with the gene acs, encodes an acetate permease in Escherichia coli.”  Gimenez R.et.al.   14563880
[5] “Protein complexes of the Escherichia coli cell envelope.”  Stenberg F.et.al.   16079137
[6] “Global topology analysis of the Escherichia coli inner membrane proteome.”  Daley D.O.et.al.   15919996

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MKRVLTALAA TLPFAANAAD AISGAVERQP TNWQAIIMFL IFVVFTLGIT YWASKRVRSR 
61:	SDYYTAGGNI TGFQNGLAIA GDYMSAASFL GISALVFTSG YDGLIYSLGF LVGWPIILFL 
121:	IAERLRNLGR YTFADVASYR LKQGPIRILS ACGSLVVVAL YLIAQMVGAG KLIELLFGLN 
181:	YHIAVVLVGV LMMMYVLFGG MLATTWVQII KAVLLLFGAS FMAFMVMKHV GFSFNNLFSE 
241:	AMAVHPKGVD IMKPGGLVKD PISALSLGLG LMFGTAGLPH ILMRFFTVSD AREARKSVFY 
301:	ATGFMGYFYI LTFIIGFGAI MLVGANPEYK DAAGHLIGGN NMAAVHLANA VGGNLFLGFI 
361:	SAVAFATILA VVAGLTLAGA SAVSHDLYAN VFKKGATERE ELRVSKITVL ILGVIAIILG 
421:	VLFENQNIAF MVGLAFAIAA SCNFPIILLS MYWSKLTTRG AMMGGWLGLI TAVVLMILGP 
481:	TIWVQILGHE KAIFPYEYPA LFSITVAFLG IWFFSATDNS AEGARERELF RAQFIRSQTG 
541:	FGVEQGRAH