2.A.22.1.11
Serotonin transporter, SERT, of 670 aas and 12 TMSs. it is subject to allosteric regulation involving 2 and possibly 3 distinct allosteric binding sites (Neubauer et al. 2006). Allosteric effectors include the transport inhibitors, duloxetine, RTI-55 and (S)-citalopram, which are antidepressants, and sometimes anti-anxiety and anti-pain medications in humans.
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| Accession Number: | Q6PWI2 |
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| Protein Name: | Transporter |
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| Length: | 670 |
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| Molecular Weight: | 74427.00 |
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| Species: | Gallus gallus (Chicken) [9031] |
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| Number of TMSs: | 11 |
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| Substrate |
serotonin |
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1: MENKATSNET QPLTSKKGIS DCNEGEDCKE NGLLIRNPKS ALRLVDDGNK VHPGQGDKEE
61: AAQISNGYSG VQSSGPCSGM GEAEDAQCTA PAATTTTTTT TSTTCGAEGQ QQLMELGDRE
121: TWSKKIDFLL SVIGYAVDLG NVWRFPYICY QNGGGAFLIP YTIMAIFGGI PLFYMELALG
181: QYHRNGCISI WRKICPIFKG IGFAICIIDL YVASYYNTIM AWVFYYLVSS FTTELPWTSC
241: NNAWNTGNCT TYFSKDNISW ALHSISPAEE FYTRQVLQVH RSNGLDDLGG ISWQLTLCLL
301: LIFIIVYFSI WKGVKTSGKV VWVTATFPYV ILFILLVRGA TLPGAWRGVL YYLKPEWQKL
361: LATEVWVDAA AQIFFSLGPG FGVLLAYASY NKFHNNCYQD ALVTSTVNCL TSFVSGFVIF
421: TVLGYMAEMR NEDVSEVAKD MGPSLLFITY AEAIANMPAS TFFAIIFFLM LLTLGLDSTF
481: AGLEGVITGV LDEFPHVWSK RREFFVLGLI IICFLGSLAT LTFGGAYVVK LFEEYATGPA
541: VLTVVFLEAV AVAWFYGITQ FCNDVKEMLG FAPGWYWRVC WVAISPIFLL FVTCSFLSNP
601: PELRLFDYNY PYWTTVVGYC IGTSSIICIP IYMAYRLIIT PGTLKERILK SITPETATEI
661: PFGDIRMNAV