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Accession Number: | Q01959 |
Protein Name: | NTDO aka DAT aka SLC6A3 aka DAT1 |
Length: | 620 |
Molecular Weight: | 68495.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | sodium(1+), dopamine, amphetamine |
Cross database links:
RefSeq: | NP_001035.1 |
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Entrez Gene ID: | 6531 |
Pfam: | PF00209 |
OMIM: |
126455 gene |
KEGG: | hsa:6531 hsa:6531 |
Gene Ontology
GO:0005737
C:cytoplasm
GO:0005887
C:integral to plasma membrane
GO:0005330
F:dopamine:sodium symporter activity
GO:0006836
P:neurotransmitter transport
GO:0030424
C:axon
GO:0016021
C:integral to membrane
GO:0043025
C:neuronal cell body
GO:0005886
C:plasma membrane
GO:0019717
C:synaptosome
GO:0035240
F:dopamine binding
GO:0005329
F:dopamine transmembrane transporter activity
GO:0008144
F:drug binding
GO:0021984
P:adenohypophysis development
GO:0007568
P:aging
GO:0008219
P:cell death
GO:0042416
P:dopamine biosynthetic process
GO:0042420
P:dopamine catabolic process
GO:0007595
P:lactation
GO:0007626
P:locomotory behavior
GO:0042136
P:neurotransmitter biosynthetic process
GO:0040018
P:positive regulation of multicellular organism growth
GO:0060134
P:prepulse inhibition
GO:0042053
P:regulation of dopamine metabolic process
GO:0051591
P:response to cAMP
GO:0042220
P:response to cocaine
GO:0042493
P:response to drug
GO:0045471
P:response to ethanol
GO:0010039
P:response to iron ion
GO:0035094
P:response to nicotine
GO:0007608
P:sensory perception of smell
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References (28)[1] “A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs.” Vandenbergh D.J.et.al. 1359373 [2] “Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.” Giros B.et.al. 1406597 [3] “Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding.” Pristupa Z.B.et.al. 8302271 [4] “Structure and organization of the gene encoding human dopamine transporter.” Kawarai T.et.al. 9300814 [5] “Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations.” Vandenbergh D.J.et.al. 10889531 [6] “Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder.” Greenwood T.A.et.al. 11304827 [7] “Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures.” Donovan D.M.et.al. 7637582 [8] “Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age.” Bannon M.J.et.al. 1353885 [9] “Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.” Torres G.E.et.al. 11343649 [10] “The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.” Carneiro A.M.D.et.al. 12177201 [11] “Characterization of single-nucleotide polymorphisms in coding regions of human genes.” Cargill M.et.al. 10391209 [12] “The consensus coding sequences of human breast and colorectal cancers.” Sjoeblom T.et.al. 16959974 [13] “A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs.” Vandenbergh D.J.et.al. 1359373 [14] “Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.” Giros B.et.al. 1406597 [15] “Pharmacological heterogeneity of the cloned and native human dopamine transporter: disassociation of [3H]WIN 35,428 and [3H]GBR 12,935 binding.” Pristupa Z.B.et.al. 8302271 [16] “Structure and organization of the gene encoding human dopamine transporter.” Kawarai T.et.al. 9300814 [17] “Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations.” Vandenbergh D.J.et.al. 10889531 [18] “Evidence for linkage disequilibrium between the dopamine transporter and bipolar disorder.” Greenwood T.A.et.al. 11304827 [19] “Sequence variation in the primate dopamine transporter gene and its relationship to social dominance.” Miller-Butterworth C.M.et.al. 17934207 [20] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [21] “Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures.” Donovan D.M.et.al. 7637582 [22] “Dopamine transporter mRNA content in human substantia nigra decreases precipitously with age.” Bannon M.J.et.al. 1353885 [23] “Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.” Torres G.E.et.al. 11343649 [24] “The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.” Carneiro A.M.D.et.al. 12177201 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MSKSKCSVGL MSSVVAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP RQSPVEAQDR 61: ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL 121: GQFNREGAAG VWKICPILKG VGFTVILISL YVGFFYNVII AWALHYLFSS FTTELPWIHC 181: NNSWNSPNCS DAHPGDSSGD SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL 241: TACLVLVIVL LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV 301: DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT SINSLTSFSS 361: GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT LPLSSAWAVV FFIMLLTLGI 421: DSAMGGMESV ITGLIDEFQL LHRHRELFTL FIVLATFLLS LFCVTNGGIY VFTLLDHFAA 481: GTSILFGVLI EAIGVAWFYG VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI 541: VTFRPPHYGA YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD 601: RELVDRGEVR QFTLRHWLKV