2.A.22.2.3
Neutral and cationic amino acid:Na⁺:Cl^- symporter, B⁰⁺ or ATB(0,+). The rat homologue (NP_001032633) transports basic and zwitterionic amino acids, but not proline, aspartic acid and glutamic acid (Uchiyama et al, 2008). The stoichiometry of Na⁺:Cl^-:amino acid = 3:1:1 (Le Guellec et al. 2022). SLC6A14 depends on heat shock protein HSP90 for trafficking to the cell surface (Rogala-Koziarska et al. 2019). It is upregulated in some forms of cancer; residues important for function have been identified (Palazzolo et al. 2019). Flagellin from Pseudomonas aeruginosa stimulates the ATB(0,+) transporter for arginine and neutral amino acids in human airway epithelial cells (Barilli et al. 2021). Reshaping the binding pocket selectively reduces access for cationic aas and derivatives (Anderson et al. 2022). Machine learning identified SLC6A14 as a  biomarker promoting the proliferation and metastasis of pancreatic cancer via Wnt/β-catenin signaling (Dang et al. 2024).